基于核磁共振波谱的血小板代谢组学分析脑肿瘤
NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors.
作者信息
Pudakalakatti Shivanand, Audia Alessandra, Mukhopadhyay Anirudh, Enriquez José S, Bourgeois Dontrey, Tayob Nabihah, Zacharias Niki M, Millward Steven W, Carson Daniel, Farach-Carson Mary C, Lang Frederick F, Heimberger Amy B, Bhat Krishna P, Bhattacharya Pratip K
机构信息
Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Department of Translational Molecular Pathology, The University of Texas MD Anderson Center Center, Houston, TX 77030, USA.
出版信息
Reports (MDPI). 2021 Dec;4(4). doi: 10.3390/reports4040032. Epub 2021 Oct 1.
"Tumor-educated platelets" have recently generated substantial interest for the diagnosis of cancer. We hypothesized that tumor educated platelets from patients with brain tumors will reflect altered metabolism compared to platelets from healthy volunteers. Here, in a pilot study, we have employed nuclear magnetic resonance (NMR) spectroscopy in platelets from brain tumor patients to demonstrate altered metabolism compared to the platelets obtained from healthy volunteers.
“肿瘤驯化血小板”最近在癌症诊断方面引起了广泛关注。我们推测，与健康志愿者的血小板相比，脑肿瘤患者的肿瘤驯化血小板会反映出代谢变化。在此，在一项初步研究中，我们对脑肿瘤患者的血小板采用了核磁共振（NMR）光谱法，以证明其与从健康志愿者获得的血小板相比存在代谢变化。
Zotero 插件