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Defibrotide Has a Role in COVID-19 Therapy.

作者信息

Macciò Antonio, La Nasa Giorgio, Oppi Sara, Madeddu Clelia

机构信息

Department of Gynecologic Oncology, Azienda di Rilievo Nazionale ed Alta Specializzazione (ARNAS) G. Brotzu, and the Department of Surgical Sciences, University of Cagliari, Cagliari, Italy.

Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy; Hematology and Transplant Center, Businco Hospital, ARNAS G. Brotzu, Cagliari, Italy.

出版信息

Chest. 2022 Aug;162(2):271-273. doi: 10.1016/j.chest.2022.04.143.

DOI:10.1016/j.chest.2022.04.143
PMID:35940644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9353171/
Abstract
摘要

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Defibrotide Therapy for SARS-CoV-2 ARDS.地塞米松联合肝素与单独使用肝素治疗 COVID-19 相关急性呼吸窘迫综合征的随机对照临床试验
Chest. 2022 Aug;162(2):346-355. doi: 10.1016/j.chest.2022.03.046. Epub 2022 Apr 9.
2
Potential role of macrophage activation in mediating thrombotic complications associated with the different vaccines against COVID-19.
Eur Rev Med Pharmacol Sci. 2021 Oct;25(20):6176-6178. doi: 10.26355/eurrev_202110_26987.
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COVID-19 and cytokine storm syndrome: can what we know about interleukin-6 in ovarian cancer be applied?COVID-19 和细胞因子风暴综合征:我们对卵巢癌中白细胞介素 6 的了解能否应用于此?
J Ovarian Res. 2021 Feb 8;14(1):28. doi: 10.1186/s13048-021-00772-6.
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COVID-19: Staging of a New Disease.COVID-19:一种新型疾病的分期。
Cancer Cell. 2020 Nov 9;38(5):594-597. doi: 10.1016/j.ccell.2020.10.006. Epub 2020 Oct 10.
5
Defibrotide in the COVID-19 coagulopathy: What is the timing?去纤苷治疗新型冠状病毒肺炎凝血病:时机如何?
J Thromb Haemost. 2020 Nov;18(11):3113-3115. doi: 10.1111/jth.15100.
6
Multifactorial pathogenesis of COVID-19-related coagulopathy: Can defibrotide have a role in the early phases of coagulation disorders?新冠病毒相关凝血病的多因素发病机制:去纤苷在凝血障碍早期阶段能发挥作用吗?
J Thromb Haemost. 2020 Nov;18(11):3106-3108. doi: 10.1111/jth.15021.
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COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure.COVID-19 导致的血管内皮损伤:补体、HIF-1 和 ABL2 是损伤的潜在途径和治疗靶点。
Ann Hematol. 2020 Aug;99(8):1701-1707. doi: 10.1007/s00277-020-04138-8. Epub 2020 Jun 24.
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Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages.COVID-19 患者的病理性炎症:单核细胞和巨噬细胞的关键作用。
Nat Rev Immunol. 2020 Jun;20(6):355-362. doi: 10.1038/s41577-020-0331-4. Epub 2020 May 6.
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.中国武汉成人 COVID-19 住院患者的临床病程和死亡危险因素:一项回顾性队列研究。
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