Birt D F, Pelling J C, Pour P M, Tibbels M G, Schweickert L, Bresnick E
Carcinogenesis. 1987 Jul;8(7):913-7. doi: 10.1093/carcin/8.7.913.
Studies were conducted to evaluate the ability of dietary dried cabbage supplements to inhibit pancreatic carcinogenesis in hamsters and skin tumorigenesis in mice. Pancreatic cancer was induced by treatment with 40 mg/kg body wt N-nitrosobis-(2-oxopropyl)amine (BOP). Cabbage was fed from before carcinogen treatment in low fat diet and, beginning 1 week after BOP treatment, cabbage was given in low fat and high fat diets in comparison with the respective non-cabbage-containing diets. Dried cabbage was incorporated at 9 and 11% levels into the low and high fat diets. Feeding cabbage in the high fat diet elevated the yield of BOP-induced pancreatic ductular carcinoma (1.6 carcinomas/effective animal) in comparison with that observed in hamsters fed cabbage in a low fat diet or in those given a high fat diet without cabbage, 0.6-0.8 carcinomas/effective animal (P less than 0.05). Furthermore, the incidence of BOP-induced gall bladder adenocarcinoma was elevated in cabbage-fed hamsters irrespective of dietary fat intake. Effects of dietary fat and cabbage on food consumption, body weight, and serum T3 and T4 values are described. Skin tumorigenesis was induced in SENCAR mice by 10 nmol 7,12 dimethylbenz[a]anthracene (DMBA) and promoted beginning 1 week later with twice weekly applications of 2 micrograms 12-O-tetradecanoyl-13-phorbol acetate (TPA). Dried cabbage was incorporated into AIN semi-purified diets from before DMBA treatment and throughout TPA treatment. Skin papilloma yield was elevated in DMBA-initiated TPA-promoted mice that were fed diets containing 10% cabbage. Mice fed cabbage developed an average of 8.45 papillomas per mouse following 22 weeks of promotion while mice given control diet developed 7.25 papillomas per mouse (P less than 0.001). Cabbage feeding did not influence survival, food consumption or body weight of the mice. These results suggest the need for further research on the use of cabbage as a chemopreventive measure.
开展了多项研究，以评估食用干白菜补充剂抑制仓鼠胰腺癌发生及小鼠皮肤肿瘤发生的能力。通过给仓鼠注射40毫克/千克体重的N-亚硝基双-(2-氧代丙基)胺（BOP）诱导胰腺癌。在致癌物处理前，将白菜添加到低脂饮食中喂养仓鼠；从BOP处理1周后开始，将白菜分别添加到低脂和高脂饮食中，并与各自不含白菜的饮食进行比较。干白菜分别以9%和11%的比例添加到低脂和高脂饮食中。与低脂饮食喂养白菜的仓鼠或高脂饮食但不含白菜的仓鼠相比（分别为0.6 - 0.8例癌/有效动物），高脂饮食喂养白菜的仓鼠中，BOP诱导的胰腺导管癌发生率升高（1.6例癌/有效动物）（P < 0.05）。此外，无论饮食脂肪摄入量如何，喂食白菜的仓鼠中BOP诱导的胆囊腺癌发生率均升高。描述了饮食脂肪和白菜对食物消耗、体重以及血清T3和T4值的影响。通过给SENCAR小鼠涂抹10纳摩尔的7,12-二甲基苯并[a]蒽（DMBA）诱导皮肤肿瘤发生，并在1周后开始促进，每周两次涂抹2微克的12-O-十四酰佛波醇-13-乙酸酯（TPA）。从DMBA处理前直至整个TPA处理期间，将干白菜添加到AIN半纯化饮食中。在DMBA启动、TPA促进的小鼠中，喂食含10%白菜饮食的小鼠皮肤乳头瘤发生率升高。在促进22周后，喂食白菜的小鼠平均每只小鼠长出8.45个乳头瘤，而喂食对照饮食的小鼠平均每只小鼠长出7.25个乳头瘤（P < 0.001）。喂食白菜对小鼠的存活率、食物消耗或体重没有影响。这些结果表明，有必要进一步研究将白菜用作化学预防措施。
