Dong Z G, Liu G T, Dong Z M, Qian Y Z, An Y H, Miao J A, Zhen Y Z
Carcinogenesis. 1987 Jul;8(7):989-91. doi: 10.1093/carcin/8.7.989.
Alternaria alternata is commonly found in the grain in areas of high incidence of oesophageal cancer and is a suspected cancer-causing factor in Linxian, China. In this study, this fungus was isolated from corn in Linxian and cultured. The extract of this fungus was shown to induce 6-thioguanine-resistant mutants in V79 cells and cause transformation of NIH/3T3 mouse fibroblast cells. Metabolic activation does not seem to be required for these activities. The mutagenic and transforming activities of the extract of A. alternata suggest that this fungus may be a factor in the etiology of oesophageal cancer in Linxian.
链格孢常见于食管癌高发地区的谷物中，在中国林县它被怀疑是致癌因素。在本研究中，这种真菌从林县的玉米中分离并培养。该真菌提取物在V79细胞中可诱导6-硫鸟嘌呤抗性突变体，并导致NIH/3T3小鼠成纤维细胞发生转化。这些活性似乎不需要代谢激活。链格孢提取物的诱变和转化活性表明，这种真菌可能是林县食管癌病因中的一个因素。
