Department of Cardiology, Shandong Provincial Third Hospital, Shandong University, Jinan, 250031, Shandong, China.
Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Appl Biochem Biotechnol. 2023 Sep;195(9):5394-5408. doi: 10.1007/s12010-022-04094-1. Epub 2022 Aug 12.
The study examined the protective effects of swertiamarin on rats with experimentally induced myocardial infarction. Three to six week-old male albino Wistar rats were used in this study and experimental myocardial infarction (MI) was induced using isoproterenol. Our results showed that swertiamarin restored the alteration in heart weight, body weight, and heart weight/tibia length ratio of MI-induced rats to basal levels significantly (p < 0.05). Swertiamarin significantly (p < 0.05) restored the levels of cardiac pathophysiological marker creatine kinase (CKMB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine transaminase (ALT), and cardiac troponin I (cTn-1) to near normalcy in MI-induced rats. Levels of oxidative stress markers malondialdehyde (MDA), protein carbonyls (PC), and levels of Vitamin C and Vitamin E were significantly (p < 0.05) reverted to near basal levels in MI-induced rats by swertiamarin. Levels of the antioxidant glutathione (GSH) and antioxidant enzymes which include superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-s-transferase (GST), glutathione reductase (GR), and plasma total antioxidant capacity (TAC) were (p < 0.05) brought to near normalcy in MI-induced rats by swertiamarin. Levels of sodium (Na), potassium (k), and calcium (Ca) ATPases were significantly (p < 0.05) restored to near normalcy in MI-induced rats by swertiamarin. Status of pro-inflammatory cytokines including tumor necrosis factor (TNF-α), interleukin-6 (IL-6), and histological aberrations were also significantly (p < 0.05) restored to near normalcy in MI-induced rats by swertiamarin. Together, our results concluded that swertiamarin exerts significant cardioprotective functions in experimental MI in rats.
本研究探讨了獐牙菜苦苷对实验性心肌梗死大鼠的保护作用。本研究采用 3 至 6 周龄雄性白化 Wistar 大鼠，用异丙肾上腺素诱导实验性心肌梗死（MI）。结果表明，獐牙菜苦苷能显著恢复 MI 诱导大鼠的心脏重量、体重和心脏重量/胫骨长度比值的改变（p<0.05）。獐牙菜苦苷能显著（p<0.05）恢复 MI 诱导大鼠心肌生理标志物肌酸激酶（CKMB）、乳酸脱氢酶（LDH）、天门冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）和心肌肌钙蛋白 I（cTn-1）的水平接近正常。獐牙菜苦苷能显著（p<0.05）将 MDA、PC 等氧化应激标志物的水平和维生素 C 和维生素 E 的水平恢复到 MI 诱导大鼠的接近基础水平。獐牙菜苦苷能显著（p<0.05）将 GSH 和抗氧化酶（SOD、CAT、GPx、GST、GR 和血浆总抗氧化能力（TAC）的水平恢复到 MI 诱导大鼠的接近正常水平。Na、K 和 Ca ATP 酶的水平在 MI 诱导大鼠中被獐牙菜苦苷显著（p<0.05）恢复到接近正常水平。促炎细胞因子 TNF-α、IL-6 和组织学异常的状态也被獐牙菜苦苷显著（p<0.05）恢复到 MI 诱导大鼠的接近正常水平。总之，我们的结果表明，獐牙菜苦苷在大鼠实验性 MI 中发挥了显著的心脏保护作用。
