三维分子晶体的电子衍射。

UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, Los Angeles, California 90095, United States.

Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.

Chem Rev. 2022 Sep 14;122(17):13883-13914. doi: 10.1021/acs.chemrev.1c00879. Epub 2022 Aug 15.

Electron crystallography has a storied history which rivals that of its more established X-ray-enabled counterpart. Recent advances in data collection and analysis have sparked a renaissance in the field, opening a new chapter for this venerable technique. Burgeoning interest in electron crystallography has spawned innovative methods described by various interchangeable labels (3D ED, MicroED, cRED, etc.). This Review covers concepts and findings relevant to the practicing crystallographer, with an emphasis on experiments aimed at using electron diffraction to elucidate the atomic structure of three-dimensional molecular crystals.

电子晶体学有着与其更为成熟的 X 射线技术相媲美的悠久历史。近年来，数据收集和分析方面的进展引发了该领域的复兴，为这项古老技术开启了新篇章。人们对电子晶体学日益增长的兴趣催生了各种可互换标签（3D ED、MicroED、cRED 等）所描述的创新方法。本文综述了与实践晶体学家相关的概念和发现，重点介绍了旨在利用电子衍射阐明三维分子晶体原子结构的实验。