纳米酶：癌症治疗的后起之秀。

Nanozyme: a rising star for cancer therapy.

机构信息

Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China.

School of Medicine and Health, Harbin Institute of Technology, Harbin 150080, China.

出版信息

Nanoscale. 2023 Aug 3;15(30):12455-12463. doi: 10.1039/d3nr01976d.

DOI:10.1039/d3nr01976d

PMID:37462391

Abstract

In recent years, nanozymes have attracted enormous attention due to their effectiveness in promoting various catalytic reactions. To date, thousands of nanozymes have been discovered, including oxidase-like nanozymes, peroxidase-like nanozymes, and catalase-like nanozymes, covering noble metal, transition metal, and carbon nanomaterials. These nanozymes have been widely applied in various fields, including environmental protection, biosensing and nanomedicine. There are many reviews about this rising star being used in analytical chemistry. However, few works about nanozymes were related to cancer therapy. In this study, we comprehensively summarize the latest research advances on the strategies for cancer therapy based on different nanozymes. With traditional cancer treatment (including chemotherapy, radiotherapy, phototherapy), nanozyme catalytic therapy exhibited a synergistic effect for limiting the growth of tumors. Opportunities and trends for nanozymes in future cancer therapy are also discussed.

摘要

近年来，纳米酶因其在促进各种催化反应方面的有效性而引起了极大的关注。迄今为止，已经发现了数千种纳米酶，包括氧化酶样纳米酶、过氧化物酶样纳米酶和过氧化氢酶样纳米酶，涵盖了贵金属、过渡金属和碳纳米材料。这些纳米酶已广泛应用于环境保护、生物传感和纳米医学等各个领域。有许多关于这种新兴明星在分析化学中应用的评论。然而，关于纳米酶在癌症治疗方面的工作却很少。在这项研究中，我们全面总结了基于不同纳米酶的癌症治疗策略的最新研究进展。与传统的癌症治疗（包括化疗、放疗、光疗）相比，纳米酶催化治疗对肿瘤的生长具有协同抑制作用。本文还讨论了纳米酶在未来癌症治疗中的机遇和趋势。