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泰国耐碳青霉烯类 ST16 同时产 NDM-1 和 OXA-232 的克隆传播

Clonal dissemination of carbapenem-resistant ST16 co-producing NDM-1 and OXA-232 in Thailand.

作者信息

Abe Ryuichiro, Akeda Yukihiro, Takeuchi Dan, Sakamoto Noriko, Sugawara Yo, Yamamoto Norihisa, Kerdsin Anusak, Matsumoto Yuki, Motooka Daisuke, Leolerd Warawut, Santanirand Pitak, Suzuki Masato, Shibayama Keigo, Tomono Kazunori, Iida Tetsuya, Hamada Shigeyuki

机构信息

Japan-Thailand Research Collaboration Center on Emerging and Re-emerging Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.

Department of Infection Control and Prevention, Graduate School of Medicine, Osaka University, Osaka, Japan.

出版信息

JAC Antimicrob Resist. 2022 Aug 16;4(4):dlac084. doi: 10.1093/jacamr/dlac084. eCollection 2022 Aug.

DOI:10.1093/jacamr/dlac084
PMID:35983103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9380991/
Abstract

BACKGROUND

ST258 and ST11 carrying are among the most widespread carbapenem-resistant strains worldwide. Our carbapenem-resistant Enterobacteriaceae surveillance in Thailand revealed a nationwide dissemination of ST16 isolates carrying and .

OBJECTIVES

To analyse the genomic details of this nationwide dissemination by focusing on plasmids and virulence factors.

METHODS

Using WGS data of 119 ST16 isolates carrying obtained in our previous surveillance study, clonality of chromosomes and plasmids of the isolates with carriage of virulence factors was evaluated.

RESULTS

Of the 119 isolates, 111 carried plasmid pKP151_NDM1, and all 104 isolates harbouring carried plasmid pKP151_OXA232. These 104 K. pneumoniae ST16 isolates showing chromosomal clonality possessed both pKP151_NDM1 and pKP151_OXA232, demonstrating clonal dissemination of K. pneumoniae ST16 with these plasmids. The isolates had essentially similar virulence factors as those of K. pneumoniae ST16 clones carrying , which were recently reported as highly invasive clones in Brazil.

CONCLUSIONS

The potential global dissemination of these invasive clones with resistance to several antibiotics highlights the importance of appropriate monitoring and strict standard precautions.

摘要

背景

携带 blaNDM-1 和 blaOXA-232 的 ST258 和 ST11 是全球范围内最广泛传播的耐碳青霉烯菌株。我们在泰国进行的耐碳青霉烯肠杆菌科监测显示，携带 blaNDM-1 和 blaOXA-232 的 ST16 分离株在全国范围内传播。

目的

通过关注质粒和毒力因子来分析这种全国范围内传播的基因组细节。

方法

利用我们之前监测研究中获得的 119 株携带 blaNDM-1 和 blaOXA-232 的 ST16 分离株的全基因组测序数据，评估携带毒力因子的分离株的染色体和质粒的克隆性。

结果

在 119 株分离株中，111 株携带质粒 pKP151_NDM1，所有 104 株携带 blaOXA-232 的分离株都携带质粒 pKP151_OXA232。这 104 株显示染色体克隆性的肺炎克雷伯菌 ST16 分离株同时拥有 pKP151_NDM1 和 pKP151_OXA232，表明肺炎克雷伯菌 ST16 与这些质粒发生了克隆性传播。这些分离株的毒力因子与最近在巴西被报道为高侵袭性克隆的携带 blaNDM-1 和 blaOXA-232 的肺炎克雷伯菌 ST16 克隆基本相似。

结论

这些对多种抗生素耐药的侵袭性克隆在全球范围内传播的可能性凸显了适当监测和严格标准预防措施的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b0b/9380991/57f2feececef/dlac084f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b0b/9380991/4c62064cd72b/dlac084f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b0b/9380991/57f2feececef/dlac084f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b0b/9380991/4c62064cd72b/dlac084f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b0b/9380991/57f2feececef/dlac084f2.jpg

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