Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran.
Life Sci. 2022 Oct 15;307:120898. doi: 10.1016/j.lfs.2022.120898. Epub 2022 Aug 18.
Mitochondria are critical multifunctional organelles in cells that generate power, produce reactive oxygen species, and regulate cell survival. Mitochondria that are dysfunctional are eliminated via mitophagy as a way to protect cells under moderate stress and physiological conditions. However, mitophagy is a double-edged sword and can trigger cell death under severe stresses. By targeting mitochondria, photodynamic (PD) and photothermal (PT) therapies may play a role in treating cancer. These therapeutic modalities alter mitochondrial membrane potential, thereby affecting respiratory chain function and generation of reactive oxygen species promotes signaling pathways for cell death. In this regard, PDT, PTT, various mitochondrion-targeting agents and therapeutic methods could have exploited the vital role of mitochondria as the doorway to regulated cell death. Targeted mitochondrial therapies would provide an excellent opportunity for effective mitochondrial injury and accurate tumor erosion. Herein, we summarize the recent progress on the roles of PD and PT treatments in regulating cancerous cell death in relation to mitochondrial targeting and the signaling pathways involved.
线粒体是细胞中至关重要的多功能细胞器，它们产生能量、产生活性氧物种，并调节细胞存活。功能失调的线粒体通过自噬被消除，这是一种在适度应激和生理条件下保护细胞的方式。然而，自噬是一把双刃剑，在严重应激下会引发细胞死亡。通过靶向线粒体，光动力（PD）和光热（PT）疗法可能在治疗癌症方面发挥作用。这些治疗方式改变线粒体膜电位，从而影响呼吸链功能和活性氧的产生，促进细胞死亡的信号通路。在这方面，PDT、PTT、各种靶向线粒体的试剂和治疗方法可以利用线粒体作为调控细胞死亡的门户的重要作用。靶向线粒体治疗将为有效损伤线粒体和准确侵蚀肿瘤提供绝佳机会。在此，我们总结了 PD 和 PT 治疗在调节与线粒体靶向和涉及的信号通路相关的癌细胞死亡方面的最新进展。
