思考增强渗透与滞留效应（EPR）。
Thinking about Enhanced Permeability and Retention Effect (EPR).
作者信息
Leporatti Stefano
机构信息
CNR Nanotec-Istituto di Nanotecnologia, Via Monteroni, c/o Campus Ekotecne, 73100 Lecce, Italy.
出版信息
J Pers Med. 2022 Jul 30;12(8):1259. doi: 10.3390/jpm12081259.
Abstract
This invited editorial article aims at reporting progress about the enhanced permeability and retention effect (EPR for short), starting from a recent Special Issue in the (namely, "EPR Effect-Based Tumor Targeted Nanomedicine") and focusing specifically on one of these contributing articles, a review from Jun Wu entitled "The Enhanced Permeability and Retention (EPR) Effect: The Significance of the Concept and Methods to Enhance Its Application", which has recently acquired the rank of a highly cited paper [...].
摘要
这篇特邀社论旨在报道关于增强渗透与滞留效应（简称EPR效应）的进展，始于最近在《 》（即“基于EPR效应的肿瘤靶向纳米药物”）上的一期特刊，并特别聚焦于其中一篇投稿文章，吴俊撰写的一篇综述，题为《增强渗透与滞留（EPR）效应：该概念的意义及增强其应用的方法》，该文章最近已成为高被引论文[……] 。
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本文引用的文献
1
The Enhanced Permeability and Retention (EPR) Effect: The Significance of the Concept and Methods to Enhance Its Application.增强渗透与滞留（EPR）效应：概念及增强其应用方法的意义
J Pers Med. 2021 Aug 6;11(8):771. doi: 10.3390/jpm11080771.
2
The EPR effect and beyond: Strategies to improve tumor targeting and cancer nanomedicine treatment efficacy.EPR 效应及超越：提高肿瘤靶向性和癌症纳米医学治疗效果的策略。
Theranostics. 2020 Jun 25;10(17):7921-7924. doi: 10.7150/thno.49577. eCollection 2020.
3
To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?利用肿瘤微环境：既然 EPR 效应在临床上失败了，那么纳米医学的未来在哪里？
J Control Release. 2016 Dec 28;244(Pt A):108-121. doi: 10.1016/j.jconrel.2016.11.015. Epub 2016 Nov 18.
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Principles of nanoparticle design for overcoming biological barriers to drug delivery.克服药物递送生物屏障的纳米颗粒设计原则。
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EPR: Evidence and fallacy.EPR：证据与谬论。
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The link between infection and cancer: tumor vasculature, free radicals, and drug delivery to tumors via the EPR effect.感染与癌症之间的联系：肿瘤血管生成、自由基和通过 EPR 效应向肿瘤输送药物。
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Markedly enhanced permeability and retention effects induced by photo-immunotherapy of tumors.显著增强的肿瘤光免疫治疗的通透性和保留效应。
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The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo.高分子药物传递的 EPR 效应：提高肿瘤摄取率、降低全身毒性、并在体内进行独特的肿瘤成像。
Adv Drug Deliv Rev. 2013 Jan;65(1):71-9. doi: 10.1016/j.addr.2012.10.002. Epub 2012 Oct 23.
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Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner.肿瘤血管正常化以依赖尺寸的方式改善了纳米药物的递送。
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Tumor delivery of macromolecular drugs based on the EPR effect.基于 EPR 效应的大分子药物肿瘤递药。
Adv Drug Deliv Rev. 2011 Mar 18;63(3):131-5. doi: 10.1016/j.addr.2010.03.011. Epub 2010 Mar 18.
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