Maghoul Amir, Simonsen Ingve, Rostami Ali, Mirtaheri Peyman
Optical/FNIR Laboratory of Biomedical Group, Department of Mechanical, Electronics and Chemical Engineering, OsloMet-Oslo Metropolitan University, 0167 Oslo, Norway.
Department of Physics, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Nanomaterials (Basel). 2022 Aug 20;12(16):2868. doi: 10.3390/nano12162868.
The outbreak of the COVID-19 virus has faced the world with a new and dangerous challenge due to its contagious nature. Hence, developing sensory technologies to detect the coronavirus rapidly can provide a favorable condition for pandemic control of dangerous diseases. In between, because of the nanoscale size of this virus, there is a need for a good understanding of its optical behavior, which can give an extraordinary insight into the more efficient design of sensory devices. For the first time, this paper presents an optical modeling framework for a COVID-19 particle in the blood and extracts its optical characteristics based on numerical computations. To this end, a theoretical foundation of a COVID-19 particle is proposed based on the most recent experimental results available in the literature to simulate the optical behavior of the coronavirus under varying physical conditions. In order to obtain the optical properties of the COVID-19 model, the light reflectance by the structure is then simulated for different geometrical sizes, including the diameter of the COVID-19 particle and the size of the spikes surrounding it. It is found that the reflectance spectra are very sensitive to geometric changes of the coronavirus. Furthermore, the density of COVID-19 particles is investigated when the light is incident on different sides of the sample. Following this, we propose a nanosensor based on graphene, silicon, and gold nanodisks and demonstrate the functionality of the designed devices for detecting COVID-19 particles inside the blood samples. Indeed, the presented nanosensor design can be promoted as a practical procedure for creating nanoelectronic kits and wearable devices with considerable potential for fast virus detection.
由于其传染性，新冠病毒的爆发给世界带来了新的危险挑战。因此，开发能够快速检测冠状病毒的传感技术可为控制危险疾病的大流行提供有利条件。在此期间，由于这种病毒的纳米级尺寸，需要深入了解其光学行为，这可以为更高效地设计传感设备提供非凡的见解。本文首次提出了一种针对血液中新冠病毒颗粒的光学建模框架，并基于数值计算提取其光学特性。为此，基于文献中最新的实验结果，提出了新冠病毒颗粒的理论基础，以模拟冠状病毒在不同物理条件下的光学行为。为了获得新冠病毒模型的光学特性，随后针对不同的几何尺寸，包括新冠病毒颗粒的直径及其周围刺突的尺寸，模拟了该结构的光反射率。结果发现，反射光谱对冠状病毒的几何变化非常敏感。此外，还研究了光入射到样品不同侧面时新冠病毒颗粒的密度。在此基础上，我们提出了一种基于石墨烯、硅和金纳米盘的纳米传感器，并展示了所设计设备用于检测血液样本中新冠病毒颗粒的功能。事实上，所提出的纳米传感器设计可以作为一种实用方法来推广，用于制造具有快速检测病毒巨大潜力的纳米电子套件和可穿戴设备。
