甜叶（马鞭草科）叶片的毒理学特征、植物化学分析及抗炎特性
Toxicological profile, phytochemical analysis and anti-inflammatory properties of leaves of Sweet. (Verbenaceae).
作者信息
Barry Poussian Raymond, Sanou Abdoudramane, Konaté Kiessoun, Aworet-Samseny Raïssa Rr, Sytar Oksana, Dicko Mamoudou Hama
机构信息
Laboratory Biochemistry, Biotechnology, Food Technology and Nutrition (LABIOTAN), Department of Biochemistry and Microbiology, University Joseph KI-ZERBO, 03 B.P. 7021, Ouagadougou, Burkina Faso.
Applied Sciences and Technologies Training and Research Unit, Department of Biochemistry and Microbiology, University of Dedougou, B.P. 176, Dedougou, Burkina Faso.
出版信息
Heliyon. 2022 Aug 13;8(8):e10080. doi: 10.1016/j.heliyon.2022.e10080. eCollection 2022 Aug.
BACKGROUND
Natural herbal compounds are a source and alternative for new compounds with anti-inflammatory properties. Therefore, in-depth studies should be carried out to assess their safety and efficacy in order to avoid or prevent toxicological risks of these natural plant-based substances. is a species of food plant used for the treatment of inflammatory diseases in Burkina Faso. This study aimed to estimate the anti-inflammatory properties and in of the ethyl acetate fraction of the leaves of .
METHODS
To do this, acute toxicity was first evaluated on the animal model. Biological activities (carrageenan test, formalin and xylene induced oedemas) were used to assess the anti-inflammatory power.
RESULTS
Regarding the dietary toxicology of the extracts, visual and clinical signs showed that the extracts are not at the end of the 15-day (acute toxicity) and 45-day (subacute toxicity) tests. In terms of anti-inflammatory activity , it was observed that the bioactive fraction (50, 100 and 200 mg/kg.b.w) had effective neurogenic anti-inflammatory properties. All of these effects observed were all dose-dependent.
CONCLUSION
The results of this present research have proven that extracts can be used as anti-inflammatories.
背景
天然草药化合物是具有抗炎特性的新化合物的一个来源和替代品。因此，应该进行深入研究以评估它们的安全性和有效性，从而避免或预防这些天然植物性物质的毒理学风险。[植物名称]是布基纳法索一种用于治疗炎症性疾病的食用植物。本研究旨在评估[植物名称]叶乙酸乙酯部位的抗炎特性及其在[具体动物模型]中的作用。
方法
为此，首先在动物模型上评估急性毒性。采用生物活性实验（角叉菜胶实验、福尔马林和二甲苯诱导的水肿实验）来评估抗炎能力。
结果
关于提取物的饮食毒理学，视觉和临床体征表明，在15天（急性毒性）和45天（亚急性毒性）实验结束时，提取物并无毒性。在抗炎活性方面，观察到生物活性部位（50、100和200毫克/千克体重）具有有效的神经源性抗炎特性。所有观察到的这些效应均呈剂量依赖性。
结论
本研究结果证明[植物名称]提取物可作为抗炎药使用。
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