Habimana Olive, Modupe Salami Oluwabukunmi, Peng Jinfu, Yi Guang-Hui
International College, University of South China, 28, W Changsheng Road, Hengyang, Hunan 421001, China.
Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hengyang Medical School, University of South China, 28, W Changsheng Road, Hengyang, Hunan 421001, China; Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, 28, W Changsheng Road, Hengyang, Hunan 421001, China.
Biochem Pharmacol. 2022 Oct;204:115235. doi: 10.1016/j.bcp.2022.115235. Epub 2022 Aug 28.
Heart failure remains a considerable clinical and public health problem, it is the dominant cause of death from cardiovascular diseases, besides, cardiovascular diseases are one of the leading causes of death worldwide. The survival of patients with heart failure continues to be low with 45-60% reported deaths within five years. Apoptosis, necrosis, autophagy, and pyroptosis mediate cardiac cell death. Acute cell death is the hallmark pathogenesis of heart failure and other cardiac pathologies. Inhibition of pyroptosis, autophagy, apoptosis, or necrosis reduces cardiac damage and improves cardiac function in cardiovascular diseases. Pyroptosis is a form of inflammatory deliberate cell death that is characterized by the activation of inflammasomes such as NOD-like receptors (NLR), absent in melanoma 2 (AIM2), interferon-inducible protein 16 (IFI-16), and their downstream effector cytokines: Interleukin IL-1β and IL-18 leading to cell death. Recent studies have shown that pyroptosis is also the dominant cell death process in cardiomyocytes, cardiac fibroblasts, endothelial cells, and immune cells. It plays a crucial role in the pathogenesis of cardiac diseases that contribute to heart failure. This review intends to summarize the therapeutic implications targeting pyroptosis in the main cardiac pathologies preceding heart failure.
心力衰竭仍然是一个严重的临床和公共卫生问题，它是心血管疾病死亡的主要原因，此外，心血管疾病是全球主要死因之一。心力衰竭患者的生存率仍然很低，据报道，五年内死亡率为45%-60%。凋亡、坏死、自噬和焦亡介导心脏细胞死亡。急性细胞死亡是心力衰竭和其他心脏疾病的标志性发病机制。抑制焦亡、自噬、凋亡或坏死可减少心血管疾病中的心脏损伤并改善心脏功能。焦亡是一种炎症性程序性细胞死亡形式，其特征是炎性小体激活，如NOD样受体（NLR）、黑色素瘤缺乏因子2（AIM2）、干扰素诱导蛋白16（IFI-16）及其下游效应细胞因子：白细胞介素IL-1β和IL-18，导致细胞死亡。最近的研究表明，焦亡也是心肌细胞、心脏成纤维细胞、内皮细胞和免疫细胞中主要的细胞死亡过程。它在导致心力衰竭的心脏疾病发病机制中起关键作用。本综述旨在总结针对心力衰竭前主要心脏疾病中焦亡的治疗意义。
