Naz Irum, Merarchi Myriam, Ramchandani Shanaya, Khan Muhammad Rashid, Malik Muhammad Nouman, Sarwar Sumaira, Narula Acharan S, Ahn Kwang Seok
Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Faculty of Pharmacy, University of Paris Descartes, 75006 Paris, France.
Explor Target Antitumor Ther. 2020;1(3):153-170. doi: 10.37349/etat.2020.00010. Epub 2020 Jun 29.
Tanshinone is a herbal medicinal compound described in Chinese medicine, extracted from the roots of (Danshen). This family of compounds, including Tanshinone IIA and Tanshinone I, have shown remarkable potential as anti-cancer molecules, especially against breast, cervical, colorectal, gastric, lung, and prostate cancer cell lines, as well as leukaemia, melanoma, and hepatocellular carcinoma among others. Recent data has indicated that Tanshinones can modulate multiple molecular pathways such as PI3K/Akt, MAPK and JAK/STAT3, and exert their pharmacological effects against different malignancies. In addition, preclinical and clinical data, together with the safety profile of Tanshinones, encourage further applications of these compounds in cancer therapeutics. In this review article, the effect of Tanshinones on different cancers, challenges in their pharmacological development, and opportunities to harness their clinical potential have been documented.
丹参酮是一种在中医中有所记载的草药化合物，从丹参的根部提取。这类化合物，包括丹参酮IIA和丹参酮I，已显示出作为抗癌分子的巨大潜力，特别是对乳腺癌、宫颈癌、结直肠癌、胃癌、肺癌和前列腺癌细胞系，以及白血病、黑色素瘤和肝细胞癌等。最近的数据表明，丹参酮可以调节多种分子途径，如PI3K/Akt、MAPK和JAK/STAT3，并对不同的恶性肿瘤发挥其药理作用。此外，临床前和临床数据，以及丹参酮的安全性概况，都鼓励这些化合物在癌症治疗中的进一步应用。在这篇综述文章中，记录了丹参酮对不同癌症的影响、其药理开发中的挑战以及发挥其临床潜力的机会。
