Key Laboratory of Forest Plant Ecology, Ministry of Education, Engineering Research Center of Forest Bio-Preparation, College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, 150040, P. R. China.
State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, 150001, P. R. China.
Adv Healthc Mater. 2022 Nov;11(21):e2201733. doi: 10.1002/adhm.202201733. Epub 2022 Sep 1.
Manganese (Mn) has attracted widespread attention due to its low-cost, nontoxicity, and valence-rich transition. Various Mn-based nanomaterials have sprung up and are employed in diverse fields, particularly Mn-based nanozymes, which combine the physicochemical properties of Mn-based nanomaterials with the catalytic activity of natural enzymes, and are attracting a surge of research, especially in the field of biomedical research. In this review, the typical preparation strategies, catalytic mechanisms, advances and perspectives of Mn-based nanozymes for biomedical applications are systematically summarized. The application of Mn-based nanozymes in tumor therapy and sensing detection, together with an overview of their mechanism of action is highlighted. Finally, the prospective directions of Mn-based nanozymes from five perspectives: innovation, activity enhancement, selectivity, biocompatibility, and application broadening are discussed.
锰（Mn）由于其低成本、无毒和丰富的价态过渡而受到广泛关注。各种基于锰的纳米材料如雨后春笋般涌现，并应用于各个领域，特别是基于锰的纳米酶，它结合了基于锰的纳米材料的物理化学性质和天然酶的催化活性，吸引了大量的研究，特别是在生物医学研究领域。在这篇综述中，系统地总结了用于生物医学应用的基于锰的纳米酶的典型制备策略、催化机制、进展和前景。强调了基于锰的纳米酶在肿瘤治疗和传感检测中的应用，以及它们作用机制的概述。最后，从五个角度：创新、活性增强、选择性、生物相容性和应用拓宽，讨论了基于锰的纳米酶的未来方向。
