Department of Anatomy and Neuroscience, Eulji University School of Medicine, Daejeon, Korea.
Eulji Biomedical Science Research Institute, Eulji University School of Medicine, Daejeon, Korea.
Int J Nanomedicine. 2022 Aug 26;17:3711-3722. doi: 10.2147/IJN.S372494. eCollection 2022.
Magnetic particle imaging (MPI) is an emerging radiation-free, non-invasive three-dimensional tomographic technology that can visualize the concentrations of superparamagnetic iron oxide nanoparticles (SPIONs). To verify the applicability of the previously proposed point-of-care testing MPI (PoCT-MPI) in medical diagnosis and therapeutics, we imaged SPIONs in animal tumor models.
CT26 or MC38 mouse colon carcinoma cells (2 × 10 cells) were subcutaneously injected into the right flank of BALB/c mice. SPIONs were either injected directly into the tumor lesions in the intratumoral group or through tail veins in the intravenous group. CT26 and MC38 tumor models were examined both intratumorally and intravenously to confirm the biological availability of SPIONs using PoCT-MPI.
Signals were observed in the tumor lesions from day 1 to day 7. This is the first study to successfully image the pathological region and show the biodistribution of SPIONs in CT26 tumor models using the recently developed PoCT-MPI technology. Furthermore, MC38 tumor models were examined, resulting in similar images to those of the CT26 tumor model in both intratumoral and intravenous groups.
The present study demonstrates the biological applicability of PoCT-MPI, which promises to be a powerful diagnostic and therapeutic technique in biomedical imaging.
磁共振粒子成像（MPI）是一种新兴的无辐射、非侵入性的三维层析成像技术，可用于可视化超顺磁氧化铁纳米粒子（SPIONs）的浓度。为了验证先前提出的床边检测 MPI（PoCT-MPI）在医学诊断和治疗中的适用性，我们在动物肿瘤模型中对 SPIONs 进行了成像。
将 CT26 或 MC38 小鼠结肠癌细胞（2×10 个细胞）皮下注射到 BALB/c 小鼠的右侧肋腹。SPIONs 直接注射到肿瘤病变部位（瘤内组）或通过尾静脉注射到静脉内组。对 CT26 和 MC38 肿瘤模型进行瘤内和静脉内检查，以使用 PoCT-MPI 确认 SPIONs 的生物学可用性。
从第 1 天到第 7 天观察到肿瘤病变部位有信号。这是首次使用最近开发的 PoCT-MPI 技术成功对 CT26 肿瘤模型的病理区域进行成像并显示 SPIONs 的生物分布的研究。此外，还对 MC38 肿瘤模型进行了检查，结果表明在瘤内和静脉内组中，肿瘤模型的图像与 CT26 肿瘤模型的图像相似。
本研究证明了 PoCT-MPI 的生物学适用性，有望成为生物医学成像中一种强大的诊断和治疗技术。
