Artificial Intelligence Research Laboratory, Electronics and Telecommunications Research Institute (ETRI), Daejeon, Republic of Korea.
Division of Future Vehicle, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Sci Rep. 2020 Jul 16;10(1):11833. doi: 10.1038/s41598-020-68864-9.
The magnetic particle imaging (MPI) is a technology that can image the concentrations of the superparamagnetic iron oxide nanoparticles (SPIONs) which can be used in biomedical diagnostics and therapeutics as non-radioactive tracers. We proposed a point-of-care testing MPI system (PoCT-MPI) that can be used for preclinical use for imaging small rodents (mice) injected with SPIONs not only in laboratories, but also at emergency sites far from laboratories. In particular, we applied a frequency mixing magnetic detection method to the PoCT-MPI, and proposed a hybrid field free line generator to reduce the power consumption, size and weight of the system. The PoCT-MPI is [Formula: see text] in size and weighs less than 100 kg. It can image a three-dimensional distribution of SPIONs injected into a biosample with less than 120 Wh of power consumption. Its detection limit is [Formula: see text], 10 mg/mL, [Formula: see text] (Fe).
磁粒子成像（MPI）是一种可以对超顺磁氧化铁纳米粒子（SPION）浓度进行成像的技术，可作为非放射性示踪剂用于生物医学诊断和治疗。我们提出了一种可用于临床前小型啮齿动物（老鼠）成像的床边检测 MPI 系统（PoCT-MPI），不仅可以在实验室中，也可以在远离实验室的紧急地点使用。特别是，我们将频率混合磁检测方法应用于 PoCT-MPI，并提出了一种混合场无线路发生器来降低系统的功耗、尺寸和重量。PoCT-MPI 的尺寸为[Formula: see text]，重量小于 100 千克。它可以用小于 120 瓦时的功耗对注入生物样本的 SPIONs 的三维分布进行成像。其检测限为[Formula: see text]，10mg/mL，[Formula: see text]（Fe）。
