髓样细胞自噬基因可保护小鼠免受致命的 TNF-α 和 LPS 诱导的细胞因子风暴综合征的影响。
Myeloid autophagy genes protect mice against fatal TNF- and LPS-induced cytokine storm syndromes.
机构信息
Center for Infectious Disease Research, Department of Basic Medical Sciences, Tsinghua University School of Medicine, Beijing, Haidian, China.
Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, United States.
出版信息
Autophagy. 2023 Apr;19(4):1114-1127. doi: 10.1080/15548627.2022.2116675. Epub 2022 Sep 2.
ATG5: autophagy related 5; ATG7: autophagy related 7; ATG14: autophagy related 14; ATG16L1: autophagy related 16-like 1 (S. cerevisiae); BECN1: beclin 1, autophagy related; CASP1: caspase 1; CASP4/CASP11: caspase 4, apoptosis-related cysteine peptidase; CIM: conditionally immortalized macrophage; CLP: cecal ligation and puncture; CSS: cytokine storm syndrome; DC: dendritic cell; IFNG/IFNγ: interferon gamma; IFNGR1: interferon gamma receptor 1; ip: intraperitoneal; iv: intravenous; IL12/p70: interleukin 12, p70 heterodimer; IL18: Interleukin 18; ITGAX/CD11c: integrin alpha X; LAP: LC3-associated phagocytosis; LPS: lipopolysaccharide; LYZ2/LYSM: lysozyme 2; MAP1LC3A/LC3: microtubule-associated protein 1 light chain 3 alpha; RB1CC1/FIP200: RB1-inducible coiled-coil 1; S100A8/MRP8: S100 calcium binding protein A8 (calgranulin A); TICAM1/TRIF: TIR domain containing adaptor molecule 1; TLR4: toll-like receptor 4; TNF: tumor necrosis factor.
ATG5：自噬相关蛋白 5；ATG7：自噬相关蛋白 7；ATG14：自噬相关蛋白 14；ATG16L1：自噬相关蛋白 16 样蛋白 1（酿酒酵母）；BECN1：自噬相关蛋白 Beclin 1；CASP1：半胱氨酸蛋白酶 1；CASP4/CASP11：半胱天冬酶 4，凋亡相关胱天冬酶肽酶；CIM：条件永生化巨噬细胞；CLP：盲肠结扎穿孔术；CSS：细胞因子风暴综合征；DC：树突状细胞；IFNG/IFNγ：干扰素γ；IFNGR1：干扰素γ受体 1；ip：腹腔内；iv：静脉内；IL12/p70：白细胞介素 12，p70 异二聚体；IL18：白细胞介素 18；ITGAX/CD11c：整合素α X；LAP：LC3 相关吞噬作用；LPS：脂多糖；LYZ2/LYSM：溶菌酶 2；MAP1LC3A/LC3：微管相关蛋白 1 轻链 3α；RB1CC1/FIP200：RB1 诱导卷曲螺旋 1；S100A8/MRP8：S100 钙结合蛋白 A8（钙粒蛋白 A）；TICAM1/TRIF：TIR 结构域包含衔接子分子 1；TLR4： toll 样受体 4；TNF：肿瘤坏死因子。
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