Otvos J D, Coffer M C, Chen S M, Wehrli S
Biochem Biophys Res Commun. 1987 Jun 30;145(3):1397-403. doi: 10.1016/0006-291x(87)91593-2.
The ratio of intensity (RI) of the plasma lipid methyl proton NMR resonance from two Carr-Purcell-Meiboom-Gill spectra acquired with a short (2.4 msec) and long (120 msec) pulse delay time is proposed to provide a potentially more sensitive and less variable marker of human malignancy than the linewidth parameter previously suggested (E.T. Fossel, J.M. Carr, and J. McDonagh (1986) N. Engl. J. Med. 315, 1369-1376). Linewidth and transverse (T2) relaxation data are presented which demonstrate that the observed correlation between methyl and methylene lipid linewidth and the methyl RI parameter arises from a combination of T2 differences and the relative amounts that fast- and slow-relaxing components contribute to the composite methyl resonance.
通过短（2.4毫秒）和长（120毫秒）脉冲延迟时间采集的两个卡-普-迈-吉尔（Carr-Purcell-Meiboom-Gill）谱所得到的血浆脂质甲基质子核磁共振共振强度比（RI），被认为可能是一种比先前提出的线宽参数更敏感且变化更小的人类恶性肿瘤标志物（E.T. 福塞尔、J.M. 卡尔和J. 麦克多纳（1986年）《新英格兰医学杂志》315卷，第1369 - 1376页）。文中给出了线宽和横向（T2）弛豫数据，这些数据表明，观察到的甲基和亚甲基脂质线宽与甲基RI参数之间的相关性，是由T2差异以及快速和慢速弛豫成分对复合甲基共振的相对贡献量共同导致的。
