光子核化学：从电子加速器辐照汞中获得医用金同位素。

Photonuclear Alchemy: Obtaining Medical Isotopes of Gold from Mercury Irradiated on Electron Accelerators.

机构信息

Radiochemistry Laboratory, Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences (GEOKHI RAS), Kosygin St., 19, 119991 Moscow, Russia.

Department of Physics, Lomonosov Moscow State University (MSU), Leninskie Gory, 1, Bld. 2, 119991 Moscow, Russia.

出版信息

Molecules. 2022 Aug 28;27(17):5532. doi: 10.3390/molecules27175532.

DOI:10.3390/molecules27175532

PMID:36080299

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9457897/

Abstract

In our work, the photonuclear production of Au isotopes for nuclear medicine purposes was studied, and a method for their recovery from irradiated mercury was developed. The yields of the corresponding nuclear reactions were determined, and a comparison of various methods of obtaining gold radioisotopes was provided. New sorbents based on benzo-15-crown-5, which selectively binds gold, were studied, and the optimal conditions for Au recovery with a high degree of purification from mercury were found. It was established that, for the fast and quantitative recovery of Au isotopes, it was necessary to add at least 0.1 mg of the carrier. As a result, the developed method can be regularly used to obtain Au for the research of radiopharmaceuticals based on them.

摘要

在我们的工作中，研究了用于核医学目的的金同位素的光致核反应生成，并开发了从辐照汞中回收它们的方法。确定了相应核反应的产率，并提供了各种获得金放射性同位素方法的比较。研究了基于苯并-15-冠-5 的新型吸附剂，该吸附剂选择性地结合金，找到了从汞中高度纯化回收金的最佳条件。结果表明，为了快速定量回收金同位素，有必要添加至少 0.1 毫克的载体。因此，所开发的方法可定期用于获得 Au，用于研究基于它们的放射性药物。