School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China.
School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China.
Int J Biol Macromol. 2022 Dec 1;222(Pt A):30-40. doi: 10.1016/j.ijbiomac.2022.09.054. Epub 2022 Sep 9.
Uncontrolled hemorrhage of deep, narrow, and non-compressible perforating wounds is responsible for many trauma deaths. In this study, a rapid hemostatic sponge with an orderly channel based on methacrylated collagen (ColMA) was prepared via directional freeze-drying technology. The methacrylated hyaluronate (HAMA) was added to further enhance the mechanical properties of the sponge. The sponge presents excellent mechanical strength, rapid shape recovery, and absorption speed, which was faster than those of many reported natural polymer hemostatic sponges. Moreover, ColMA/HAMA sponge showed much better blood-clotting capacity and superior hemostasis performance than commercially available collagen sponges in vitro and in the rat-liver injury model. This study demonstrated a feasible strategy to construct the rapid hemostatic sponge with an orderly channel for the deep and non-compressible perforating wound.
深度、狭窄且不可压缩的贯通性创伤导致的无法控制的出血是许多创伤死亡的原因。在这项研究中，通过定向冷冻干燥技术制备了一种基于甲基丙烯酰化胶原蛋白（ColMA）的具有有序通道的快速止血海绵。添加甲基丙烯酰化透明质酸（HAMA）以进一步增强海绵的机械性能。该海绵具有优异的机械强度、快速的形状恢复和吸收速度，比许多报道的天然聚合物止血海绵更快。此外，ColMA/HAMA 海绵在体外和大鼠肝损伤模型中表现出比市售胶原蛋白海绵更好的凝血能力和卓越的止血性能。本研究为构建用于深部和不可压缩的贯通性创伤的具有有序通道的快速止血海绵提供了一种可行的策略。
