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鉴定出 IDO1、ALDH2、NCOA2、SLC7A5、SLC3A2、LDHB 和 HPRT1 等与代谢相关的基因作为潜在的预后标志物，并与头颈部鳞状细胞癌中的免疫浸润相关联。

Identify metabolism-related genes IDO1, ALDH2, NCOA2, SLC7A5, SLC3A2, LDHB, and HPRT1 as potential prognostic markers and correlate with immune infiltrates in head and neck squamous cell carcinoma.

机构信息

Department of Otorhinolaryngology, Qilu Hospital of Shandong University, National Health Commission (NHC) Key Laboratory of Otorhinolaryngology (Shandong University), Jinan, China.

出版信息

Front Immunol. 2022 Aug 25;13:955614. doi: 10.3389/fimmu.2022.955614. eCollection 2022.

DOI:10.3389/fimmu.2022.955614
PMID:36090994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9455275/
Abstract

Hypopharyngeal squamous cell carcinoma (HSCC) is a kind of head and neck squamous cell carcinoma (HNSCC) with poor prognosis. Metabolic reprogramming may regulate the tumor microenvironment (TME) by adapting quickly to cellular stress and regulating immune response, but its role in HSCC has not been reported. We used the nCounter Metabolic Pathways Panel to investigate metabolic reprogramming, cellular stress, and their relationship in HSCC tissues and adjacent normal tissues. Metabolism-related pathways nucleotide synthesis and glycolysis pathways were significantly upregulated, while amino acid synthesis and fatty acid oxidation pathways were significantly downregulated in HSCC tissues compared to adjacent normal tissues. There is a significant correlation between metabolism-related pathways and cellular stress pathways. Enrichment of immune cell and tumor infiltrating lymphocyte (TIL) analysis showed changes in immune responses between HSCC tissues and adjacent normal tissues. Overall survival analysis showed that upregulated genes CD276, LDHB, SLC3A2, EGFR, SLC7A5, and HPRT1 are potential unfavorable prognostic markers in HNSCC, while downregulated genes EEA1, IDO1, NCOA2, REST, CCL19, and ALDH2 are potential favorable prognostic markers in HNSCC. Moreover, metabolism-related genes IDO1, ALDH2, NCOA2, SLC7A5, SLC3A2, LDHB, and HPRT1 are correlated with immune infiltrates in HNSCC. These results suggest that metabolic reprogramming occurs and correlates with cellular stress and immune response in HSCC, which may help researchers understand mechanisms of metabolic reprogramming and develop effective immunotherapeutic strategies in HNSCC.

摘要

下咽鳞状细胞癌 (HSCC) 是一种预后不良的头颈部鳞状细胞癌 (HNSCC)。代谢重编程可以通过快速适应细胞应激和调节免疫反应来调节肿瘤微环境 (TME)，但其在 HSCC 中的作用尚未报道。我们使用 nCounter 代谢途径面板来研究 HSCC 组织和相邻正常组织中的代谢重编程、细胞应激及其关系。与相邻正常组织相比，HSCC 组织中核苷酸合成和糖酵解途径等代谢相关途径显著上调，而氨基酸合成和脂肪酸氧化途径显著下调。代谢相关途径与细胞应激途径之间存在显著相关性。免疫细胞和肿瘤浸润淋巴细胞 (TIL) 分析的富集显示 HSCC 组织和相邻正常组织之间的免疫反应发生了变化。总体生存分析表明，上调基因 CD276、LDHB、SLC3A2、EGFR、SLC7A5 和 HPRT1 是 HNSCC 中潜在的不利预后标志物，而下调基因 EEA1、IDO1、NCOA2、REST、CCL19 和 ALDH2 是 HNSCC 中潜在的有利预后标志物。此外，代谢相关基因 IDO1、ALDH2、NCOA2、SLC7A5、SLC3A2、LDHB 和 HPRT1 与 HNSCC 中的免疫浸润相关。这些结果表明，代谢重编程发生并与 HSCC 中的细胞应激和免疫反应相关，这可能有助于研究人员了解代谢重编程的机制，并为 HNSCC 开发有效的免疫治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fb/9455275/dd24064c7690/fimmu-13-955614-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fb/9455275/20f8aadfab49/fimmu-13-955614-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fb/9455275/7bfcb579e01b/fimmu-13-955614-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fb/9455275/357a7e960e44/fimmu-13-955614-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fb/9455275/226ec3a421c6/fimmu-13-955614-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fb/9455275/f3db9a8566c5/fimmu-13-955614-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fb/9455275/4331e55edac5/fimmu-13-955614-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fb/9455275/15b0ef5dba06/fimmu-13-955614-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fb/9455275/dd24064c7690/fimmu-13-955614-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fb/9455275/20f8aadfab49/fimmu-13-955614-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fb/9455275/7bfcb579e01b/fimmu-13-955614-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fb/9455275/357a7e960e44/fimmu-13-955614-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fb/9455275/226ec3a421c6/fimmu-13-955614-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fb/9455275/f3db9a8566c5/fimmu-13-955614-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fb/9455275/4331e55edac5/fimmu-13-955614-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fb/9455275/15b0ef5dba06/fimmu-13-955614-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fb/9455275/dd24064c7690/fimmu-13-955614-g008.jpg

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