Department of Materials Science and Engineering, Yonsei University, Seoul 03722, Republic of Korea.
Center for Nanomedicine, Institute for Basic Science (IBS), Yonsei University, Seoul 03722, Republic of Korea.
Sci Adv. 2022 Sep 16;8(37):eabq0897. doi: 10.1126/sciadv.abq0897. Epub 2022 Sep 14.
The in situ diagnosis of cardiac activities with simultaneous therapeutic electrical stimulation of the heart is key to preventing cardiac arrhythmia. Here, we present an unconventional single-device platform that enables in situ monitoring even in a wet condition and control of beating heart motions without interferences to the recording signal. This platform consists of the active-matrix array of pressure-sensitive transistors for detecting cardiac beatings, biocompatible, low-impedance electrodes for cardiac stimulations, and an alginate-based hydrogel adhesive for attaching this platform conformally to the epicardium. In contrast to conventional electrophysiological sensing using electrodes, the pressure-sensitive transistors measured mechanophysiological characteristics by monitoring the spatiotemporal distributions of cardiac pressures during heart beating motions. In vivo tests show mechanophysiological readings having good correlation with electrocardiography and negligible interference with the electrical artifacts caused during cardiac stimulations. This platform can therapeutically synchronize the rhythm of abnormal heartbeats through efficient pacing of cardiac arrhythmia.
原位诊断心脏活动并同时对心脏进行治疗性电刺激是预防心律失常的关键。在这里，我们提出了一种非传统的单器件平台，即使在湿润条件下也能实现原位监测，并且在不干扰记录信号的情况下控制心脏跳动。该平台由用于检测心跳的压敏晶体管有源矩阵阵列、用于心脏刺激的生物相容性低阻抗电极以及用于将该平台顺应性地附着于心外膜的藻酸盐基水凝胶粘合剂组成。与使用电极的传统电生理传感不同，压敏晶体管通过监测心脏跳动过程中心脏压力的时空分布来测量力学生理特性。体内测试表明，力学生理读数与心电图具有良好的相关性，并且与心脏刺激过程中产生的电伪影几乎没有干扰。该平台可以通过对心律失常进行有效的起搏来治疗性地使异常心跳同步。
