Abuzenada Basem Mohammed, Sonbul Helal M
Department of Restorative Dentistry, Faculty of Dentistry, King Abdulaziz University, Jeddah, Batterjee Medical College, Jeddah, Saudi Arabia.
J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S13-S18. doi: 10.4103/jpbs.jpbs_128_22. Epub 2022 Jul 13.
The aim of this systematic review was to assess the therapeutic effect of remineralizing and antibacterial potential of resin-based nanocomposites compared with conventional composite with/without fluoride release in naturally occurring and post-orthodontic carious lesions.
The literature search covered the electronic databases, such as PubMed, EBSCO, and Google scholar, from 2012 to 2021. Only articles published in English were included. Randomized controlled trials (RCT) and studies were included. All studies which met eligibility criteria were reviewed by two independent reviewers.
The processes involved in the selection of studies were presented in Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines for study screening. Finally, based on the eligibility criteria, 13 studies were selected. The remineralizing effects of nanocomposites were compared with conventional composites in clinical trials and studies.
Nanotechnological interventions could be used to improve the therapeutic efficiency in reducing demineralization and growth of the biofilm. Further well-designed clinical trials with long-term follow-up are essential to elucidate the clinical relevance of remineralizing agents.
本系统评价旨在评估与具有/不具有氟释放功能的传统复合材料相比，树脂基纳米复合材料在天然和正畸后龋损中的再矿化和抗菌潜力的治疗效果。
文献检索涵盖了2012年至2021年的电子数据库，如PubMed、EBSCO和谷歌学术。仅纳入以英文发表的文章。纳入随机对照试验（RCT）和研究。所有符合纳入标准的研究均由两名独立的评审员进行评审。
研究选择过程按照系统评价和Meta分析的首选报告项目中研究筛选指南进行呈现。最后，根据纳入标准，选择了13项研究。在临床试验和研究中比较了纳米复合材料与传统复合材料的再矿化效果。
纳米技术干预可用于提高减少脱矿和生物膜生长的治疗效率。进一步设计良好且有长期随访的临床试验对于阐明再矿化剂的临床相关性至关重要。
