Wang Xiang Yu, Liu Qiang, Zhang Wen Xiang, Wang Tian, Wang Nian Chang, Wang Zhong Zhao, Fang Yi, Kong Xiang Yi, Wang Jing
Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chaoyang, Beijing 100021, China.
These authors contributed equally to this work.
World J Oncol. 2022 Aug;13(4):172-184. doi: 10.14740/wjon1460. Epub 2022 Aug 23.
Coronavirus disease 2019 (COVID-19) is a global pandemic. Breast cancer is the most commonly diagnosed malignant cancer in China. Considering the specific national conditions, no evidence is available for factors associated with COVID-19 vaccination in patients with breast cancer.
This was a cross-sectional survey, fielded from June 21 through June 27, 2021. A total of 944 nationally representative samples of Chinese breast cancer patients participating in the survey were included. Participant surveys included questions addressing who finished COVID-19 vaccination with the question "Have you taken the COVID-19 vaccine?", and response options were "Yes" and "No".
Overall, 730 (77.33%) women with breast cancer were unvaccinated, and only 214 (22.67%) were vaccinated with the COVID-19 vaccine. After adjusting for potential confounders, including both sociodemographic and clinical characteristics, we found that external support, including positive doctor suggestions (odds ratio (OR): 5.52; 95% confidence interval (CI): 3.50 - 8.71; P < 0.0001), positive support from surrounding people (OR: 11.65; 95% CI: 7.57 - 17.91; P < 0.0001), and negative initiative from the community (OR: 0.15; 95% CI: 0.06 - 0.35; P < 0.0001), was associated with COVID-19 vaccination rates among breast cancer patients. These results remain stable in subgroup analyses. We found that most participants (82.52%) understood the necessity of COVID-19 vaccinations in China was strong; however, the recognition regarding the COVID-19 vaccine showed different patterns between vaccinated and unvaccinated participants.
Our findings suggest external support, including vaccination suggestions from surgeons or oncologists, vaccination suggestions from associated people, and residents' committee mandated vaccinations, was associated with the COVID-19 vaccination rates. Interventions regarding these factors and improving publicity as well as education regarding COVID-19 vaccines among breast cancer patients are warranted.
2019冠状病毒病（COVID-19）是一场全球大流行疾病。乳腺癌是中国最常被诊断出的恶性肿瘤。考虑到具体国情，目前尚无关于乳腺癌患者中与COVID-19疫苗接种相关因素的证据。
这是一项横断面调查，于2021年6月21日至6月27日进行。总共纳入了944名参与调查的具有全国代表性的中国乳腺癌患者样本。参与者调查问卷包括“你接种过COVID-19疫苗吗？”这一询问是否完成COVID-19疫苗接种的问题，回答选项为“是”和“否”。
总体而言，730名（77.33%）乳腺癌女性未接种疫苗，只有214名（22.67%）接种了COVID-19疫苗。在对包括社会人口统计学和临床特征在内的潜在混杂因素进行调整后，我们发现外部支持，包括医生的积极建议（比值比（OR）：5.52；95%置信区间（CI）：3.50 - 8.71；P < 0.0001）、周围人的积极支持（OR：11.65；95% CI：7.57 - 17.91；P < 0.0001）以及社区的负面倡议（OR：0.15；95% CI：0.06 - 0.35；P < 0.0001），与乳腺癌患者的COVID-19疫苗接种率相关。这些结果在亚组分析中保持稳定。我们发现大多数参与者（82.52%）认为在中国接种COVID-19疫苗的必要性很强；然而，接种和未接种参与者对COVID-19疫苗的认知呈现出不同模式。
我们的研究结果表明，外部支持，包括外科医生或肿瘤学家的疫苗接种建议、相关人员的疫苗接种建议以及居民委员会强制接种疫苗，与COVID-19疫苗接种率相关。有必要针对这些因素进行干预，并加强对乳腺癌患者的COVID-19疫苗宣传和教育。
