生物活性天然产物在微生物化学防治中的应用：科学展望（2001-2021）和系统评价。

Bioactive Natural Products for Chemical Control of Microorganisms: Scientific Prospecting (2001-2021) and Systematic Review.

机构信息

Faculty of Food Engineering, State University of Campinas, Monteiro Lobato, 80, University City "Zeferino Vaz", Campinas 13083-862, SP, Brazil.

Academic Unit of Food Technology, Federal University of Campina Grande, Jairo Vieira Feitosa, 1770, Pombal 58840-000, Pereiros, PB, Brazil.

出版信息

Molecules. 2022 Sep 12;27(18):5917. doi: 10.3390/molecules27185917.

DOI:10.3390/molecules27185917

PMID:36144652

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9505009/

Abstract

The inappropriate use of synthetic antibiotics has become a global public health problem. Therefore, the study of new alternatives for the treatment of infectious diseases is relevant and natural bioactive products are on the rise. This study conducted a scientific prospection of bioactive natural products with promising applications in the chemical control of microorganisms. A systematic review of the most recent articles was performed according to the following three steps: (i) eligibility assessment, (ii) screening, and (iii) inclusion of articles and information extraction. There has been an increase in the number of scientific publications on bioactive natural products for microbial control in the CAPES and SciELO databases (2001-2021). Seventeen relevant articles were included, most of which focused on extracts. Ascorbic acid, chlorogenic acid, chrysin, and quercetin were the most cited compounds. Natural products were shown to be effective in inhibiting more than 30 microorganisms. A discussion was presented on the research trends.

摘要

不合理使用合成抗生素已成为全球公共卫生问题。因此，研究治疗传染病的新替代品具有重要意义，天然生物活性产品也应运而生。本研究对具有应用于微生物化学控制前景的生物活性天然产物进行了科学展望。按照以下三个步骤对最近的文章进行了系统回顾：（i）资格评估，（ii）筛选，以及（iii）文章纳入和信息提取。在 CAPES 和 SciELO 数据库（2001-2021 年）中，有关微生物控制的生物活性天然产物的科学出版物数量有所增加。共纳入了 17 篇相关文章，其中大多数都集中在提取物上。抗坏血酸、绿原酸、白杨素和槲皮素是引用最多的化合物。天然产物在抑制 30 多种微生物方面表现出了有效性。本文还对研究趋势进行了讨论。