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寻常性炎性痤疮粉刺内容物中的微生物群由Spp.及其他皮肤微生物过度生长组成。

The Microbiome in Comedonal Contents of Inflammatory Acne Vulgaris is Composed of an Overgrowth of Spp. and Other Cutaneous Microorganisms.

作者信息

Akaza Narifumi, Takasaki Kazuto, Nishiyama Eri, Usui Atsuko, Miura Shiori, Yokoi Aya, Futamura Kyoko, Suzuki Kayoko, Yashiro Youichi, Yagami Akiko

机构信息

Research Laboratories, Nippon Menard Cosmetic Co., Ltd., Nagoya, Japan.

Fasmac Co., Ltd., Kanagawa, Japan.

出版信息

Clin Cosmet Investig Dermatol. 2022 Sep 21;15:2003-2012. doi: 10.2147/CCID.S379609. eCollection 2022.

DOI:10.2147/CCID.S379609
PMID:36172249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9510696/
Abstract

BACKGROUND

Acne vulgaris (acne) and cutaneous resident microorganisms are considered to be closely related. However, the bacterial and fungal microbiota in the comedonal contents of inflammatory acne lesions have not yet been investigated in detail.

PURPOSE

To clarify the relationship between cutaneous microorganisms and acne, we examined the microbiome in the comedonal contents of inflammatory acne and on the facial skin of patients with acne using 16s rRNA and ITS gene sequencing with a next-generation sequencer (NGS).

PATIENTS AND METHODS

Twenty-two untreated Japanese acne outpatients were examined. The comedonal contents of inflammatory acne lesions on the face were collected using a comedo extractor. Skin surface samples from facial skin were collected using the swab method.

RESULTS

The results obtained revealed that the predominant bacteria in the comedonal contents of inflammatory acne were spp. (more prominent in areas with large amounts of sebum), while those on the skin surface were spp. spp., particularly , were the predominant fungi in both the comedonal contents of inflammatory acne and on the skin surface. The bacterial microbiome in comedonal contents exhibited stronger metabolic activity, including the production of enzymes related to acne, than that on the skin surface.

CONCLUSION

These results indicate that acne is an inflammatory disease involving the overgrowth of and other cutaneous resident microorganisms, including spp.

摘要

背景

寻常痤疮（痤疮）与皮肤常驻微生物被认为密切相关。然而，炎性痤疮皮损粉刺内容物中的细菌和真菌微生物群尚未得到详细研究。

目的

为阐明皮肤微生物与痤疮之间的关系，我们使用下一代测序仪（NGS）通过16s rRNA和ITS基因测序，检测了炎性痤疮粉刺内容物及痤疮患者面部皮肤的微生物组。

患者与方法

对22名未经治疗的日本痤疮门诊患者进行检查。使用粉刺挤压器收集面部炎性痤疮皮损的粉刺内容物。采用拭子法收集面部皮肤表面样本。

结果

所得结果显示，炎性痤疮粉刺内容物中的主要细菌为 菌属（在皮脂分泌量大的区域更为突出），而皮肤表面的主要细菌为 菌属。 菌属，尤其是 菌属，是炎性痤疮粉刺内容物和皮肤表面的主要真菌。粉刺内容物中的细菌微生物组表现出比皮肤表面更强的代谢活性，包括与痤疮相关酶的产生。

结论

这些结果表明，痤疮是一种涉及 菌属和其他皮肤常驻微生物（包括 菌属）过度生长的炎症性疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/9510696/0033e58493de/CCID-15-2003-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/9510696/635d1e6f6926/CCID-15-2003-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/9510696/cb34836aea80/CCID-15-2003-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/9510696/761245eeed50/CCID-15-2003-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/9510696/6a9ac2a02eaa/CCID-15-2003-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/9510696/eb4ecb54cbcc/CCID-15-2003-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/9510696/69c2b98a1563/CCID-15-2003-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/9510696/0033e58493de/CCID-15-2003-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/9510696/635d1e6f6926/CCID-15-2003-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/9510696/cb34836aea80/CCID-15-2003-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/9510696/761245eeed50/CCID-15-2003-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/9510696/6a9ac2a02eaa/CCID-15-2003-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/9510696/eb4ecb54cbcc/CCID-15-2003-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/9510696/69c2b98a1563/CCID-15-2003-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/9510696/0033e58493de/CCID-15-2003-g0007.jpg

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