Long-term air pollution exposure and COVID-19 case-severity: An analysis of individual-level data from Switzerland.

Several studies are pointing out that exposure to elevated air pollutants could contribute to increased COVID-19 mortality. However, literature on the associations between air pollution exposure and COVID-19 severe morbidity is rather sparse. In addition, the majority of the studies used an ecological study design and were applied in regions with rather high air pollution levels. Here, we study the differential effects of long-term exposure to air pollution on severe morbidity and mortality risks from COVID-19 in various population subgroups in Switzerland, a country known for clean air. We perform individual-level analyses using data covering the first two major waves of COVID-19 between February 2020 and May 2021. High-resolution maps of particulate matter (PM) and nitrogen dioxide (NO) concentrations were produced for the 6 years preceding the pandemic using Bayesian geostatistical models. Air pollution exposure for each patient was measured by the long-term average concentration across the municipality of residence. The models were adjusted for the effects of individual characteristics, socio-economic, health-system, and climatic factors. The variables with an important association to COVID-19 case-severity were identified using Bayesian spatial variable selection. The results have shown that the individual-level characteristics are important factors related to COVID-19 morbidity and mortality in all the models. Long-term exposure to air pollution appears to influence the severity of the disease only when analyzing data during the first wave; this effect is attenuated upon adjustment for health-system related factors during the entire study period. Our findings suggest that the burden of air pollution increased the risks of COVID-19 in Switzerland during the first wave of the pandemic, but not during the second wave, when the national health system was better prepared.