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气候变化、人类健康和暴露组学:利用组学技术应对不确定的时代。

Climate change, human health, and the exposome: Utilizing OMIC technologies to navigate an era of uncertainty.

机构信息

Institute of Global Health and Human Ecology, The American University in Cairo, New Cairo, Egypt.

出版信息

Front Public Health. 2022 Sep 21;10:973000. doi: 10.3389/fpubh.2022.973000. eCollection 2022.

DOI:10.3389/fpubh.2022.973000
PMID:36211706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9533016/
Abstract

Climate change is an anthropogenic phenomenon that is alarming scientists and non-scientists alike. The emission of greenhouse gases is causing the temperature of the earth to rise and this increase is accompanied by a multitude of climate change-induced environmental exposures with potential health impacts. Tracking human exposure has been a major research interest of scientists worldwide. This has led to the development of exposome studies that examine internal and external individual exposures over their lifetime and correlate them to health. The monitoring of health has also benefited from significant technological advances in the field of "omics" technologies that analyze physiological changes on the nucleic acid, protein, and metabolism levels, among others. In this review, we discuss various climate change-induced environmental exposures and their potential health implications. We also highlight the potential integration of the technological advancements in the fields of exposome tracking, climate monitoring, and omics technologies shedding light on important questions that need to be answered.

摘要

气候变化是一种人为现象,令科学家和非科学家都感到震惊。温室气体的排放导致地球温度上升,而这种上升伴随着许多气候变化引起的环境暴露,可能对健康产生影响。追踪人类暴露一直是全球科学家的主要研究兴趣。这导致了暴露组学研究的发展,该研究检查了个体一生中的内部和外部暴露,并将其与健康相关联。在“组学”技术领域的重大技术进步也使健康监测受益,这些技术分析了核酸、蛋白质和代谢水平等生理变化。在这篇综述中,我们讨论了各种气候变化引起的环境暴露及其潜在的健康影响。我们还强调了在暴露组学追踪、气候监测和组学技术领域的技术进步的潜在整合,这些进步为需要回答的重要问题提供了线索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09e2/9533016/329046b49e35/fpubh-10-973000-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09e2/9533016/42e572cae7ae/fpubh-10-973000-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09e2/9533016/329046b49e35/fpubh-10-973000-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09e2/9533016/42e572cae7ae/fpubh-10-973000-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09e2/9533016/329046b49e35/fpubh-10-973000-g0002.jpg

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Environ Int. 2022 Oct;168:107422. doi: 10.1016/j.envint.2022.107422. Epub 2022 Aug 27.
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