Sagol Brain Institute Tel Aviv, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Commun Biol. 2022 Oct 18;5(1):1104. doi: 10.1038/s42003-022-04009-0.
Passive listening to music, without sound production or evident movement, is long known to activate motor control regions. Nevertheless, the exact neuroanatomical correlates of the auditory-motor association and its underlying neural mechanisms have not been fully determined. Here, based on a NeuroSynth meta-analysis and three original fMRI paradigms of music perception, we show that the long-ignored pre-motor region, area 55b, an anatomically unique and functionally intriguing region, is a core hub of music perception. Moreover, results of a brain-behavior correlation analysis implicate neural entrainment as the underlying mechanism of area 55b's contribution to music perception. In view of the current results and prior literature, area 55b is proposed as a keystone of sensorimotor integration, a fundamental brain machinery underlying simple to hierarchically complex behaviors. Refining the neuroanatomical and physiological understanding of sensorimotor integration is expected to have a major impact on various fields, from brain disorders to artificial general intelligence.
被动聆听音乐，无需发声或明显运动，长期以来被认为能激活运动控制区域。然而，听觉-运动关联的确切神经解剖学关联及其潜在的神经机制尚未完全确定。在这里，基于一个 NeuroSynth 元分析和三个原创的音乐感知 fMRI 范式，我们表明，长期被忽视的运动前区域 55b 是一个具有独特解剖结构和有趣功能的区域，是音乐感知的核心枢纽。此外，脑-行为相关性分析的结果表明，神经同步是区域 55b 对音乐感知贡献的潜在机制。鉴于目前的结果和先前的文献，区域 55b 被提议作为感觉运动整合的关键，这是一种基本的大脑机制，是简单到层次复杂行为的基础。细化感觉运动整合的神经解剖学和生理学理解有望对从大脑疾病到人工智能等各个领域产生重大影响。
