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用于治疗黑色素瘤的红细胞膜伪装金纳米颗粒

Red Blood Cell Membrane-Camouflaged Gold Nanoparticles for Treatment of Melanoma.

作者信息

Zhao Lei, Xie Hongfu, Li Ji

机构信息

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

出版信息

J Oncol. 2022 Oct 14;2022:3514984. doi: 10.1155/2022/3514984. eCollection 2022.

DOI:10.1155/2022/3514984
PMID:36276288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9586750/
Abstract

BACKGROUND

Patients with melanoma have poor response and low long-term survival to conventional cisplatin (CP). Recently, biomimetic nanoparticles have played a significant role in tumor therapy. The purpose of this study was to mechanistically evaluate the effect of red blood cell membrane camouflaged gold nanoparticles loaded with CP (RBCm@AuNPs-CP) on enhancing chemotherapy in melanoma.

METHODS

Treated B16-F10 cells with RBCm@AuNPs-CP, the antimelanoma effect was explored by detecting cell viability, apoptosis rate, level of reactive oxygen species (ROS), and singlet oxygen. RBCm@AuNPs-CP was injected into the melanoma-bearing mice via tail vein, and the target-ability, therapeutic effect, and toxicity were detected in melanoma tumor-bearing mice.

RESULTS

RBCm@AuNPs-CP had an antiproliferation and apoptosis-inducing effect on B16-F10 cells, which might be mediated by oxidative stress of ROS, and its effect was significantly enhanced compared with the CP treatment group. experiments suggested the same outcome, with better target-ability of RBCm@AuNPs-CP.

CONCLUSION

The erythrocyte camouflage nanosystem RBCm@AuNPs-CP exhibited well passive tumor target-ability and promoted apoptosis of melanocytes by inducing ROS. RBCm@AuNPs-CP as a novel safe and effective targeted drug delivery system may provide a promising choice for the treatment of melanoma.

摘要

背景

黑色素瘤患者对传统顺铂（CP）反应不佳且长期生存率低。近年来，仿生纳米颗粒在肿瘤治疗中发挥了重要作用。本研究旨在从机制上评估负载顺铂的红细胞膜伪装金纳米颗粒（RBCm@AuNPs-CP）对增强黑色素瘤化疗效果的作用。

方法

用RBCm@AuNPs-CP处理B16-F10细胞，通过检测细胞活力、凋亡率、活性氧（ROS）水平和单线态氧来探究其抗黑色素瘤作用。将RBCm@AuNPs-CP经尾静脉注射到荷黑色素瘤小鼠体内，检测其在荷黑色素瘤小鼠中的靶向能力、治疗效果和毒性。

结果

RBCm@AuNPs-CP对B16-F10细胞具有抗增殖和诱导凋亡作用，这可能是由ROS的氧化应激介导的，与顺铂治疗组相比其作用显著增强。实验得出了相同的结果，RBCm@AuNPs-CP具有更好的靶向能力。

结论

红细胞伪装纳米系统RBCm@AuNPs-CP表现出良好的被动肿瘤靶向能力，并通过诱导ROS促进黑色素细胞凋亡。RBCm@AuNPs-CP作为一种新型安全有效的靶向给药系统，可能为黑色素瘤的治疗提供一个有前景的选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/bf83c47058c3/JO2022-3514984.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/be33dc7c6555/JO2022-3514984.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/25d390a70f49/JO2022-3514984.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/8ce821fba460/JO2022-3514984.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/6c6c96db1a63/JO2022-3514984.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/436880cba188/JO2022-3514984.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/45ac9421346e/JO2022-3514984.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/ec68b8edf741/JO2022-3514984.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/2b6c2296b9e2/JO2022-3514984.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/7c2dabfdeaa4/JO2022-3514984.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/bf83c47058c3/JO2022-3514984.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/be33dc7c6555/JO2022-3514984.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/25d390a70f49/JO2022-3514984.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/8ce821fba460/JO2022-3514984.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/6c6c96db1a63/JO2022-3514984.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/436880cba188/JO2022-3514984.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/45ac9421346e/JO2022-3514984.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/ec68b8edf741/JO2022-3514984.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/2b6c2296b9e2/JO2022-3514984.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/7c2dabfdeaa4/JO2022-3514984.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/761b/9586750/bf83c47058c3/JO2022-3514984.010.jpg

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