Mussin Javier, Giusiano Gustavo
Mycology Department, Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Instituto de Medicina Regional, Universidad Nacional del Nordeste (UNNE), Resistencia, Argentina.
Front Chem. 2022 Oct 6;10:1023542. doi: 10.3389/fchem.2022.1023542. eCollection 2022.
In recent years, an increase in multidrug-resistant fungal strains has been observed, which, together with the limited number of clinically available antifungal agents, highlights the need for the development of new antifungal agents. Due to the proven antifungal activity of silver nanoparticles (AgNPs), there is a growing interest in their use in the treatment of fungal infections. Nanoparticles are usually synthesised through a variety of physical and chemical processes that are costly and pollute the environment. For this reason, biogenic synthesis is emerging as an environmentally friendly technology and new strategies are increasingly based on the use of biogenic AgNPs as antifungal agents for clinical use. The aim of this review is to compare the antifungal activity of different biogenic AgNPs and to summarise the current knowledge on the mechanisms of action and resistance of fungi to AgNPs. Finally, a general analysis of the toxicity of biogenic AgNPs in human and veterinary medicine is performed.
近年来，已观察到多重耐药真菌菌株有所增加，再加上临床上可用的抗真菌药物数量有限，凸显了开发新型抗真菌药物的必要性。由于银纳米颗粒（AgNPs）已被证实具有抗真菌活性，人们对其在真菌感染治疗中的应用兴趣日益浓厚。纳米颗粒通常通过各种物理和化学过程合成，这些过程成本高昂且会污染环境。因此，生物合成作为一种环境友好型技术正在兴起，新策略越来越多地基于使用生物合成的AgNPs作为临床用抗真菌剂。本综述的目的是比较不同生物合成AgNPs的抗真菌活性，并总结目前关于真菌对AgNPs的作用机制和耐药性的知识。最后，对生物合成AgNPs在人类医学和兽医学中的毒性进行了综合分析。
