中国疫情期间精神障碍患者 COVID-19 疫苗接种率：一项横断面研究。

COVID-19 vaccination coverage among patients with psychiatric disorders in China during the pandemic: a cross-sectional study.

机构信息

Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, 410011, Changsha, Hunan, China.

出版信息

BMC Psychiatry. 2022 Oct 26;22(1):659. doi: 10.1186/s12888-022-04271-w.

DOI:10.1186/s12888-022-04271-w

PMID:36289487

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9597954/

Abstract

BACKGROUND

To investigate the Coronavirus Disease 2019 (COVID-19) vaccination coverage and the influential factors of vaccination among patients with mental disorders, we conducted a cross-sectional study in China.

METHOD

The anonymous questionnaires including demographic data, vaccination status, intention to be vaccinated and its reasons were collected in the Second Xiangya Hospital, one of the biggest four psychiatric centers in China. Mental health of these participants were measured by the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder-7 items (GAD-7). The influential factors associated with vaccination status were analyzed by Fisher exact tests and binary logistical analysis.

RESULT

1328 patients and 922 family members completed the survey. The vaccination rate of patients included was 69.4%, whereas 85.5% patients were willing to be vaccinated. Being hospitalized (aOR 0.41, 95% CI:0.27-0.60), suffering from schizophrenia (aOR 0.38, 95% CI: 0.19-0.75) and secondary school educational background (aOR 0.58, 95% CI: 0.37-0.93) were significantly associated with less likelihood to get vaccinated. Uptaking vaccines could reduce depressive (aOR 0.63, 95% CI: 0.41-0.98) or anxious symptoms (aOR 0.40, 95% CI: 0.25-0.63) in these patients for a short period.

CONCLUSION

Further COVID-19 immunization programme should prioritize hospitalized psychiatric patients and schizophrenic patients since their demands for vaccination had been partly ignored during the current inoculation.

摘要

背景

为了调查精神障碍患者的 2019 年冠状病毒病（COVID-19）疫苗接种覆盖率和接种的影响因素，我们在中国进行了一项横断面研究。

方法

在我国最大的四家精神病中心之一的湘雅二院，收集了包括人口统计学数据、疫苗接种状况、接种意愿及其原因的匿名问卷。这些参与者的心理健康状况通过患者健康问卷（PHQ-9）和广泛性焦虑障碍-7 项（GAD-7）进行测量。通过 Fisher 精确检验和二元逻辑分析，分析与接种状况相关的影响因素。

结果

共 1328 名患者和 922 名家属完成了调查。患者的疫苗接种率为 69.4%，而 85.5%的患者愿意接种疫苗。住院（比值比 0.41，95%可信区间：0.27-0.60）、患有精神分裂症（比值比 0.38，95%可信区间：0.19-0.75）和中学教育背景（比值比 0.58，95%可信区间：0.37-0.93）与较低的接种可能性显著相关。接种疫苗可以在短期内降低患者的抑郁（比值比 0.63，95%可信区间：0.41-0.98）或焦虑症状（比值比 0.40，95%可信区间：0.25-0.63）。