用[具体物质]增强[相关物质]的生物活性成分以减轻人皮肤成纤维细胞中血红素加氧酶诱导的氧化应激。 （注：原文中部分内容缺失，翻译可能不够完整准确，需结合完整原文进一步完善）
Enhancing Bioactive Components of with to Reduce HO-Induced Oxidative Stress in Human Skin Fibroblasts.
作者信息
Jiang Yanbing, You Shiquan, Zhang Yongtao, Zhao Jingsha, Wang Dongdong, Zhao Dan, Li Meng, Wang Changtao
机构信息
Beijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100040, China.
Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing 100040, China.
出版信息
Antioxidants (Basel). 2022 Sep 23;11(10):1881. doi: 10.3390/antiox11101881.
This study investigated the effects of fermentation on the oxidative stress attenuating effects of on HO-induced human skin fibroblasts (HSF). The results showed that fermentation (i) increases the content of the various bioactive components of and is found to have smaller molecular weights of polysaccharides and polypeptides; (ii) increases the overall intracellular and extracellular antioxidant capacity of HO-induced HSF while reducing reactive oxygen species (ROS) levels. Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) all showed simultaneous increases in activity. Aside from that, the Nrf2 and MAPK signaling pathways are activated to regulate downstream-associated proteins such as the Bax/Bcl-2 protein ratio, matrix metalloproteinase 1 (MMP-1) activity, and human type I collagen (COL-1). These results suggested that the fermentation of with enhances its antioxidant capacity and attenuates apoptosis and senescence caused by oxidative stress.
本研究调查了发酵对**[物质名称缺失]诱导人皮肤成纤维细胞（HSF）氧化应激减轻作用的影响。结果表明，发酵（i）增加了[物质名称缺失]各种生物活性成分的含量，且发现多糖和多肽的分子量更小；（ii）增加了[物质名称缺失]诱导的HSF细胞内和细胞外的总体抗氧化能力，同时降低了活性氧（ROS）水平。超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）和过氧化氢酶（CAT）的活性均同时增加。除此之外，Nrf2和MAPK信号通路被激活，以调节下游相关蛋白，如Bax/Bcl-2蛋白比值、基质金属蛋白酶1（MMP-1）活性和人I型胶原蛋白（COL-1）。这些结果表明，[物质名称缺失]与[物质名称缺失]**发酵增强了其抗氧化能力，并减轻了氧化应激引起的细胞凋亡和衰老。
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