Kozłowski Mateusz, Michalczyk Kaja, Witczak Grzegorz, Kwiatkowski Sebastian, Mirecka Aneta, Nowak Katarzyna, Pius-Sadowska Ewa, Machaliński Bogusław, Cymbaluk-Płoska Aneta
Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Department of Obstetrics and Gynecology, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Antioxidants (Basel). 2022 Oct 13;11(10):2024. doi: 10.3390/antiox11102024.
It is relevant to find new prognostic and diagnostic biomarkers for endometrial cancer. The study group consisted of 94 cases of endometrial cancer, the control group of 65 cases of normal endometrium. We evaluated PON1 and PTX3 serum levels. The ROC curve was plotted. The area under the curve was calculated to characterize the sensitivity and specificity of the studied parameters. Univariate and multivariate analyses were performed simultaneously using the Cox regression model. The Kaplan-Meier curve was used to assess survival. The cut-off level of PON1 was 142.6 ng/mL, with a sensitivity and specificity of 79 and 84% ( = 0.0321). The cut-off level of PTX3 was 4.2 ng/mL, with a sensitivity and specificity of 63 and 57% ( = 0.028). The favorable prognostic factor determined in serum was PON1 (for PFS: HR 0.93, 95% CI 0.86-1.03, = 0.046; for OS: HR 0.96, 95% CI 0.89-1.08, = 0.009). PON1 may be considered a potential biomarker in the diagnosis of endometrial cancer. Considering multivariate analysis, the PON1 serum level above the median is an independent favourable prognostic factor affecting PFS and OS. Considering Kaplan-Meier curves, longer recurrence-free survival and overall survival were found in patients with PON1 levels below the median. In view of the inconclusive results, we suggest that further studies should be conducted.
寻找子宫内膜癌新的预后和诊断生物标志物具有重要意义。研究组由94例子宫内膜癌患者组成，对照组为65例正常子宫内膜患者。我们评估了血清中对氧磷酶1（PON1）和3型五聚素（PTX3）的水平。绘制了ROC曲线。计算曲线下面积以表征所研究参数的敏感性和特异性。同时使用Cox回归模型进行单因素和多因素分析。采用Kaplan-Meier曲线评估生存率。PON1的临界值为142.6 ng/mL，敏感性和特异性分别为79%和84%（P = 0.0321）。PTX3的临界值为4.2 ng/mL，敏感性和特异性分别为63%和57%（P = 0.028）。血清中确定的有利预后因素是PON1（无进展生存期：风险比[HR] 0.93，95%置信区间[CI] 0.86 - 1.03，P = 0.046；总生存期：HR 0.96，95% CI 0.89 - 1.08，P = 0.009）。PON1可被视为子宫内膜癌诊断中的一种潜在生物标志物。考虑多因素分析，血清PON1水平高于中位数是影响无进展生存期和总生存期的独立有利预后因素。根据Kaplan-Meier曲线，发现PON1水平低于中位数的患者无复发生存期和总生存期更长。鉴于结果尚无定论，我们建议应进行进一步研究。
