Jiang Di, Liu Shaowei, Tang Wenlai
College of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing 210037, China.
Jiangsu Yuyue Medical Equipment and Supply Co., Ltd., Danyang 212300, China.
Micromachines (Basel). 2022 Oct 2;13(10):1659. doi: 10.3390/mi13101659.
Non-spherical shape is a general appearance feature for bioparticles. Therefore, a mechanical mechanism study of non-spherical particle migration in a microfluidic chip is essential for more precise isolation of target particles. With the manipulation of non-spherical particles, refined disease detection or medical intervention for human beings will be achievable in the future. In this review, fabrication and manipulation of non-spherical particles are discussed. Firstly, various fabrication methods for non-spherical microparticle are introduced. Then, the active and passive manipulation techniques for non-spherical particles are briefly reviewed, including straight inertial microchannels, secondary flow inertial microchannels and deterministic lateral displacement microchannels with extremely high resolution. Finally, applications of viscoelastic flow are presented which obviously increase the precision of non-spherical particle separation. Although various techniques have been employed to improve the performance of non-spherical particle manipulation, the universal mechanism behind this has not been fully discussed. The aim of this review is to provide a reference for non-spherical particle manipulation study researchers in every detail and inspire thoughts for non-spherical particle focused device design.
非球形是生物颗粒的一种常见外观特征。因此，研究非球形颗粒在微流控芯片中的迁移力学机制对于更精确地分离目标颗粒至关重要。通过对非球形颗粒的操控，未来有望实现对人类疾病的精准检测或医疗干预。在这篇综述中，将讨论非球形颗粒的制备与操控。首先，介绍了多种制备非球形微粒的方法。然后，简要回顾了非球形颗粒的主动和被动操控技术，包括直惯性微通道、二次流惯性微通道以及具有极高分辨率的确定性侧向位移微通道。最后，介绍了粘弹性流的应用，其显著提高了非球形颗粒分离的精度。尽管已采用各种技术来提高非球形颗粒操控的性能，但其背后的通用机制尚未得到充分讨论。本综述的目的是为非球形颗粒操控研究的人员提供详细参考，并为专注于非球形颗粒的设备设计提供思路。
