Global Urgent and Advanced Research and Development (GUARD), 911 Rue Principale, Batiscan, QC G0X 1A0, Canada.
Viruses. 2022 Sep 28;14(10):2139. doi: 10.3390/v14102139.
Bunyaviruses represent the largest group of RNA viruses and are the causative agent of a variety of febrile and hemorrhagic illnesses. Originally characterized as a single serotype in Africa, the number of described bunyaviruses now exceeds over 500, with its presence detected around the world. These predominantly tri-segmented, single-stranded RNA viruses are transmitted primarily through arthropod and rodent vectors and can infect a wide variety of animals and plants. Although encoding for a small number of proteins, these viruses can inflict potentially fatal disease outcomes and have even developed strategies to suppress the innate antiviral immune mechanisms of the infected host. This short review will attempt to provide an overall description of the order , describing the mechanisms behind their infection, replication, and their evasion of the host immune response. Furthermore, the historical context of these viruses will be presented, starting from their original discovery almost 80 years ago to the most recent research pertaining to viral replication and host immune response.
布尼亚病毒属于最大的 RNA 病毒群，是多种发热和出血性疾病的病原体。最初在非洲被鉴定为单一血清型，如今已发现的布尼亚病毒超过 500 种，在世界各地均有存在。这些主要为三片段、单链 RNA 病毒主要通过节肢动物和啮齿动物媒介传播，可感染多种动植物。尽管编码少量蛋白，但这些病毒可引起潜在致命的疾病后果，甚至发展出抑制受感染宿主固有抗病毒免疫机制的策略。本综述将尝试概述该目，描述其感染、复制和逃避宿主免疫反应的机制。此外，还将介绍这些病毒的历史背景，从近 80 年前的最初发现到最近关于病毒复制和宿主免疫反应的研究。
