School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia.
Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy in St. Louis, St. Louis, MO, United States.
Front Public Health. 2022 Oct 10;10:972378. doi: 10.3389/fpubh.2022.972378. eCollection 2022.
Cardiovascular disease is the most prevalent health problem associated with poorer health-related quality of life (HRQoL). We aimed to assess HRQoL and treatment satisfaction of cardiovascular disease patients in Ethiopia.
A cross-sectional survey was conducted among adults attending the outpatient cardiac clinic at Tikur Anbessa Specialized Hospital from July to September 2021. Patients were recruited consecutively during follow-up visits. Treatment Satisfaction Questionnaire for Medication and European Quality of life questionnaires were used to evaluate treatment satisfaction and HRQoL, respectively. Kruskal-Wallis and Mann-Whitney -tests were used to compare utility weights between patient subgroups. Utility values were computed using disutility weights of the Ethiopian general population derived using a hybrid regression model. Tobit regression modeling was used to explore factors associated with poor HRQoL. Statistical significance was determined at < .
A total of 357 patients participated in the study with a mean age of 49.3 ± 17.8 years. The most frequently reported health problems were pain/discomfort (75.4%), followed by mobility (73.4%). The median (interquartile range) European Quality questionnaires five dimensions with five levels utility (EQ-5D-5L) and European Quality of life Visual Analog Scale scores were 0.84 (0.55-0.92) and 70.0 (50.0-85.0), respectively. The highest and lowest mean (standard deviation) treatment satisfaction scores were for the convenience and safety satisfaction dimensions: 87.7 (17.9) and 53.1 (33.5), respectively. Unemployment, older age, previous hospital admission, non-adherence to lifestyle modification, and presence of three or more cardiovascular disease factors were significantly negatively associated with HRQoL.
Overall, the study found that cardiovascular disease had a profound negative effect on HRQoL and patient treatment satisfaction. We suggest that interventions to enhance HRQoL and treatment satisfactions should focus on modifiable associated factors including lifestyle changes and controlling disease progression.
心血管疾病是与较差的健康相关生活质量（HRQoL）相关的最普遍的健康问题。我们旨在评估埃塞俄比亚心血管疾病患者的 HRQoL 和治疗满意度。
2021 年 7 月至 9 月，在提克安贝萨专科医院的门诊心脏诊所对成年人进行了一项横断面调查。在随访期间连续招募患者。使用治疗满意度问卷药物和欧洲生活质量问卷分别评估治疗满意度和 HRQoL。Kruskal-Wallis 和 Mann-Whitney-U 检验用于比较患者亚组之间的效用权重。使用混合回归模型得出的埃塞俄比亚一般人群的不效用权重计算效用值。Tobit 回归模型用于探索与较差 HRQoL 相关的因素。统计显著性定义为 <.
共有 357 名患者参加了研究，平均年龄为 49.3 ± 17.8 岁。报告的最常见健康问题是疼痛/不适（75.4%），其次是活动能力受限（73.4%）。欧洲生活质量问卷五维五分制（EQ-5D-5L）和欧洲生活质量视觉模拟量表的中位数（四分位距）分别为 0.84（0.55-0.92）和 70.0（50.0-85.0）。最高和最低的平均（标准差）治疗满意度评分分别是便利性和安全性满意度维度：87.7（17.9）和 53.1（33.5）。失业、年龄较大、以前住院、不遵守生活方式改变以及存在三个或更多心血管疾病因素与 HRQoL 显著负相关。
总体而言，该研究发现心血管疾病对 HRQoL 和患者治疗满意度有深远的负面影响。我们建议，应针对可改变的相关因素（包括生活方式改变和控制疾病进展），采取干预措施来提高 HRQoL 和治疗满意度。
