Vijayan Vikram, Wang Zikun, Chandra Vikram, Chakravorty Arun, Li Rufei, Sarbanes Stephanie L, Akhlaghpour Hessameddin, Maimon Gaby
Laboratory of Integrative Brain Function and Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.
Sci Adv. 2022 Oct 28;8(43):eabn3852. doi: 10.1126/sciadv.abn3852.
To better understand how animals make ethologically relevant decisions, we studied egg-laying substrate choice in . We found that flies dynamically increase or decrease their egg-laying rates while exploring substrates so as to target eggs to the best, recently visited option. Visiting the best option typically yielded inhibition of egg laying on other substrates for many minutes. Our data support a model in which flies compare the current substrate's value with an internally constructed expectation on the value of available options to regulate the likelihood of laying an egg. We show that dopamine neuron activity is critical for learning and/or expressing this expectation, similar to its role in certain tasks in vertebrates. Integrating sensory experiences over minutes to generate an estimate of the quality of available options allows flies to use a dynamic reference point for judging the current substrate and might be a general way in which decisions are made.
为了更好地理解动物如何做出与行为学相关的决策，我们研究了[具体物种]的产卵底物选择。我们发现，果蝇在探索底物时会动态地增加或降低其产卵率，以便将卵产在最近访问过的最佳选项上。选择最佳选项通常会导致在许多分钟内抑制在其他底物上产卵。我们的数据支持这样一个模型，即果蝇将当前底物的价值与内部构建的对可用选项价值的预期进行比较，以调节产卵的可能性。我们表明，多巴胺神经元活动对于学习和/或表达这种预期至关重要，这类似于它在脊椎动物某些任务中的作用。在几分钟内整合感官体验以生成对可用选项质量的估计，使果蝇能够使用动态参考点来判断当前底物，这可能是做出决策的一种普遍方式。
