Li Xiang, Wu Junsong, Kang Yijun, Chen Dan, Chen Guijie, Zeng Xiaoxiong, Wang Jialian
School of Marine and Biological Engineering, Yancheng Teachers' University, Yancheng, China.
Department of Basic Medical Science, Jiangsu Vocational College of Medicine, Yancheng, China.
Front Nutr. 2022 Oct 14;9:1019344. doi: 10.3389/fnut.2022.1019344. eCollection 2022.
The yeast mannoproteins (MPs), a major component of yeast cell walls with large exploration potentiality, have been attracting increasing attention due to their beneficial effects. However, the information about the anti-obesogenic activity of MPs is still limited. Thus, the effects of MPs on the high-fat diet (HFD)-induced obesity and dysbiosis of gut microbiota were investigated in this work. The results showed that MPs could significantly attenuate the HFD-induced higher body weight, fat accumulation, liver steatosis, and damage. Simultaneously, the inflammation in HFD-induced mice was also ameliorated by MPs. The pyrosequencing analysis showed that intervention by MPs could lead to an obvious change in the structure of gut microbiota. Furthermore, the prevention of obesity by MPs is highly linked to the promotion of (increased from 0.39 ± 0.12% to 2.10 ± 0.20%) and inhibition of (decreased from 19.99 ± 3.94% to 2.68 ± 0.77%). Moreover, the increased level of acetate (increased from 3.28 ± 0.22 mmol/g to 7.84 ± 0.96 mmol/g) and activation of G protein-coupled receptors (GPRs) by MPs may also contribute to the prevention of obesity. Thus, our preliminary findings revealed that MPs from yeast could be explored as potential prebiotics to modulate the gut microbiota and prevent HFD-induced obesity.
酵母甘露糖蛋白（MPs）是酵母细胞壁的主要成分，具有很大的开发潜力，因其有益作用而受到越来越多的关注。然而，关于MPs抗肥胖活性的信息仍然有限。因此，本研究探讨了MPs对高脂饮食（HFD）诱导的肥胖和肠道微生物群失调的影响。结果表明，MPs可显著减轻HFD诱导的体重增加、脂肪堆积、肝脏脂肪变性和损伤。同时，MPs还改善了HFD诱导小鼠的炎症反应。焦磷酸测序分析表明，MPs干预可导致肠道微生物群结构发生明显变化。此外，MPs预防肥胖与促进（从0.39±0.12%增加到2.10±0.20%）和抑制（从19.99±3.94%降低到2.68±0.77%）密切相关。此外，MPs使乙酸盐水平升高（从3.28±0.22 mmol/g增加到7.84±0.96 mmol/g）以及激活G蛋白偶联受体（GPRs）也可能有助于预防肥胖。因此，我们的初步研究结果表明，酵母来源的MPs有望作为潜在的益生元来调节肠道微生物群并预防HFD诱导的肥胖。
