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基于钛酸盐纳米带的纳米生物杂交体在再生医学中的潜在应用

Titanate nanoribbon-based nanobiohybrid for potential applications in regenerative medicine.

作者信息

Maurizi Lionel, Bellat Vanessa, Moreau Mathieu, De Maistre Emmanuel, Boudon Julien, Dumont Laure, Denat Franck, Vandroux David, Millot Nadine

机构信息

Laboratoire Interdisciplinaire Carnot de Bourgogne, UMR 6303 CNRS/Université Bourgogne Franche-Comté 9 Avenue Alain Savary BP 47870 21078 Dijon France

Société NVH Medicinal Dijon France

出版信息

RSC Adv. 2022 Sep 21;12(41):26875-26881. doi: 10.1039/d2ra04753e. eCollection 2022 Sep 16.

DOI:10.1039/d2ra04753e
PMID:36320832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9490774/
Abstract

Nanoparticles capable of mimicking natural tissues represent a major technological advancement in regenerative medicine. In this pilot study, the development of a new nanohybrid composed of titanate nanoribbons to mimic the extracellular matrix is reported. During the first phase, nanoribbons were synthesized by hydrothermal treatment. Subsequently, titanate nanoribbons were functionalized by heterobifunctional polyethylene-glycol (PEG) to graft type I collagen on their surface. Biological properties of this new nanobiohybrid such as cytotoxicity to cardiac cells and platelet aggregation ability were evaluated. The so-formed nanobiohybrid permits cellular adhesion and proliferation favoring fine cardiac tissue healing and regeneration.

摘要

能够模拟天然组织的纳米颗粒代表了再生医学的一项重大技术进步。在这项初步研究中，报告了一种由钛酸酯纳米带组成的新型纳米杂化物的开发，以模拟细胞外基质。在第一阶段，通过水热处理合成纳米带。随后，通过异双功能聚乙二醇（PEG）对钛酸酯纳米带进行功能化，以在其表面接枝I型胶原蛋白。评估了这种新型纳米生物杂化物的生物学特性，如对心脏细胞的细胞毒性和血小板聚集能力。如此形成的纳米生物杂化物允许细胞粘附和增殖，有利于心脏组织的良好愈合和再生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2371/9490774/36d4b09b7cd1/d2ra04753e-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2371/9490774/c4fb2c485930/d2ra04753e-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2371/9490774/6a1fbe0d3018/d2ra04753e-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2371/9490774/36d4b09b7cd1/d2ra04753e-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2371/9490774/c4fb2c485930/d2ra04753e-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2371/9490774/6a1fbe0d3018/d2ra04753e-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2371/9490774/36d4b09b7cd1/d2ra04753e-f3.jpg

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