Department for Evidence-based Medicine and Evaluation, Danube University Krems, Krems, Austria.
Haus der Barmherzigkeit Tokiostraße, Vienna, Austria.
Sci Rep. 2022 Nov 4;12(1):18725. doi: 10.1038/s41598-022-22013-6.
Aim of this study was investigate the prevalence and incidence of atrial fibrillation (AF) and to describe the clinical characteristics, risk profiles, and types of anticoagulant therapy for stroke prevention and the clinical outcomes in persons admitted to a long-term care hospital. We conducted a retrospective cohort study using data from the electronic medical records of patients aged 65 years or older living in two long-term care hospitals between January 1, 2014 and October 31, 2017. Overall data from 1148 patients (mean age 84.1 ± 7.9 years, 74.2% women) were analyzed. At baseline, the median CHADS-VASc score was 4 (IQR 3-5) and the HAS-BLED score 2 (IQR 2-3). We observed patients over a median period of 3.7 years. The point prevalence of AF was 29.6% (95% CI 25.8-33.7) on January 1, 2014. The 1-year cumulative incidence of de novo AF was 4.0% (2.8-5.6). Oral anticoagulants were prescribed in 48% of patients with AF. The cumulative incidence at 1 year for a composite outcome of TIA, stroke, or systemic arterial embolism was 0.6% (0.1-3.1) and 1.7% (0.5-4.6) and for bleeding 2.6% (0.9-6.2) and 1.8% (0.5-4.8) in patients with AF and oral anticoagulants or no oral anticoagulants, respectively. In long-term care hospital patients, we observed a high burden of AF. However, only about half of patients with AF received oral anticoagulation for stroke prevention.
本研究旨在调查心房颤动(AF)的患病率和发病率,并描述预防中风的抗凝治疗的临床特征、风险概况和类型,以及长期护理医院患者的临床结局。我们使用了 2014 年 1 月 1 日至 2017 年 10 月 31 日期间居住在两家长期护理医院的年龄在 65 岁及以上的患者的电子病历中的数据进行了回顾性队列研究。共分析了 1148 例患者(平均年龄 84.1±7.9 岁,74.2%为女性)的总体数据。基线时,CHADS-VASc 评分中位数为 4(IQR 3-5),HAS-BLED 评分中位数为 2(IQR 2-3)。我们观察了患者中位时间为 3.7 年。2014 年 1 月 1 日,AF 的点患病率为 29.6%(95%CI 25.8-33.7)。新发 AF 的 1 年累积发生率为 4.0%(2.8-5.6)。48%的 AF 患者服用了口服抗凝剂。AF 患者中,1 年时 TIA、中风或全身性动脉栓塞的复合结局发生率为 0.6%(0.1-3.1)和 1.7%(0.5-4.6),出血发生率为 2.6%(0.9-6.2)和 1.8%(0.5-4.8),分别服用口服抗凝剂和未服用口服抗凝剂。在长期护理医院患者中,我们观察到 AF 负担很高。然而,只有约一半的 AF 患者接受了口服抗凝剂预防中风。