Barajas Carlos, Del Vecchio Domitilla
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Curr Opin Biotechnol. 2022 Dec;78:102837. doi: 10.1016/j.copbio.2022.102837. Epub 2022 Nov 4.
Natural biological systems display complex regulation and synthetic biomolecular systems have been used to understand their natural counterparts and to parse sophisticated regulations into core design principles. At the same time, the engineering of biomolecular systems has unarguable potential to transform current and to enable new, yet-to-be-imagined, biotechnology applications. In this review, we discuss the progression of control systems design in synthetic biology, from the purpose of understanding the function of naturally occurring regulatory motifs to that of creating genetic circuits whose function is sufficiently robust for biotechnology applications.
天然生物系统展现出复杂的调控，合成生物分子系统已被用于理解其天然对应物，并将复杂的调控解析为核心设计原则。与此同时，生物分子系统工程在变革现有生物技术以及实现全新的、尚未想象到的生物技术应用方面具有无可争议的潜力。在本综述中，我们讨论了合成生物学中控制系统设计的进展，从理解天然存在的调控基序的功能这一目的，到创建功能对于生物技术应用而言足够稳健的遗传电路。
