Luciano Keven, Wang Xiaochuan, Liu Yaning, Eyler Gabriella, Qin Zhenpeng, Xia Xiaohu
Department of Chemistry, University of Central Florida, Orlando, FL 32816, USA.
School of Social Work, College of Health Professions and Sciences, University of Central Florida, Orlando, FL 32816, USA.
Bioengineering (Basel). 2022 Nov 8;9(11):666. doi: 10.3390/bioengineering9110666.
Point-of-care (POC) tests for the diagnosis of diseases are critical to the improvement of the standard of living, especially for resource-limited areas or countries. In recent years, nanobiosensors based on noble metal nanoparticles (NM NPs) have emerged as a class of effective and versatile POC testing technology. The unique features of NM NPs ensure great performance of associated POC nanobiosensors. In particular, NM NPs offer various signal transduction principles, such as plasmonics, catalysis, photothermal effect, and so on. Significantly, the detectable signal from NM NPs can be tuned and optimized by controlling the physicochemical parameters (e.g., size, shape, and elemental composition) of NPs. In this article, we introduce the inherent merits of NM NPs that make them attractive for POC testing, discuss recent advancement of NM NPs-based POC tests, highlight their social impacts, and provide perspectives on challenges and opportunities in the field. We hope the review and insights provided in this article can inspire new fundamental and applied research in this emerging field.
用于疾病诊断的即时检测（POC）对提高生活水平至关重要，特别是对于资源有限的地区或国家。近年来，基于贵金属纳米颗粒（NM NPs）的纳米生物传感器已成为一类有效且通用的即时检测技术。NM NPs的独特特性确保了相关即时检测纳米生物传感器的出色性能。特别是，NM NPs提供了各种信号转导原理，如等离子体激元、催化、光热效应等。值得注意的是，通过控制纳米颗粒的物理化学参数（如尺寸、形状和元素组成），可以调节和优化来自NM NPs的可检测信号。在本文中，我们介绍了NM NPs使其在即时检测中具有吸引力的固有优点，讨论了基于NM NPs的即时检测的最新进展，强调了它们的社会影响，并提供了该领域挑战和机遇的观点。我们希望本文提供的综述和见解能够激发这个新兴领域新的基础研究和应用研究。
