Department of Cardiology, Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, 55131 Mainz, Germany.
Int J Environ Res Public Health. 2022 Oct 25;19(21):13844. doi: 10.3390/ijerph192113844.
A series of human field studies demonstrated that simulated nocturnal traffic noise exposure impaired sleep quality and endothelial function, which could be significantly improved after intake of vitamin C in case of endothelial function. However, it remains unclear whether these changes follow a sex-specific pattern. Thus, we aimed to analyze the effect of simulated nocturnal train noise exposure on sleep quality, endothelial function and its associated changes after vitamin C intake, and other hemodynamic and biochemical parameters in young healthy men and women. We used data from a randomized crossover study, wherein 70 healthy volunteers (50% women) were each exposed to one control pattern (regular background noise) and two different train noise scenarios (30 or 60 train noise events per night, with average sound pressure levels of 52 and 54 dB(A), respectively, and peak sound level of 73-75 dB(A)) in their homes for three nights. After each night, participants visited the study center for the measurement of endothelial function as well as other hemodynamic and biochemical parameters. Sleep quality measured via self-report was significantly impaired after noise 30 and noise 60 nights in both men and women ( < 0.001 vs. control). Likewise, endothelial function measured by flow-mediated dilation (FMD) was significantly impaired after noise 30 and noise 60 nights in both men and women ( < 0.001 vs. control). While in women, vitamin C intake significantly improved FMD after both noise 30 and noise 60 study nights compared to control nights, no significant changes were observed in men. Exposure to simulated nocturnal train noise impairs sleep quality and endothelial function in both men and women, whereas a significant improvement of endothelial function after noise exposure and vitamin C intake could only be observed in women. These findings suggest for the first time that in men other mechanisms such as oxidative stress causing endothelial dysfunction may come into play.
一系列人体现场研究表明，模拟夜间交通噪声暴露会损害睡眠质量和内皮功能，而在内皮功能的情况下，摄入维生素 C 可显著改善。然而，目前尚不清楚这些变化是否具有性别特异性。因此，我们旨在分析模拟夜间火车噪声暴露对睡眠质量、内皮功能及其在摄入维生素 C 后的变化以及其他血流动力学和生化参数的影响，这些变化在年轻健康男性和女性中是否存在差异。我们使用了一项随机交叉研究的数据，其中 70 名健康志愿者（50%为女性）分别在家中接受了一种对照模式（常规背景噪声）和两种不同的火车噪声场景（每晚 30 或 60 次火车噪声事件，平均声压水平分别为 52 和 54 dB(A)，峰值声级为 73-75 dB(A))的暴露，共三晚。每晚之后，参与者都会到研究中心测量内皮功能以及其他血流动力学和生化参数。通过自我报告测量的睡眠质量在男性和女性中，在噪声 30 夜和噪声 60 夜后均显著受损（<0.001 与对照）。同样，在男性和女性中，通过血流介导的扩张（FMD）测量的内皮功能在噪声 30 夜和噪声 60 夜后均显著受损（<0.001 与对照）。然而，在女性中，与对照夜相比，维生素 C 摄入在噪声 30 夜和噪声 60 夜后均显著改善了 FMD，而在男性中则没有观察到明显变化。模拟夜间火车噪声暴露会损害男性和女性的睡眠质量和内皮功能，而在噪声暴露和维生素 C 摄入后，内皮功能的显著改善仅在女性中观察到。这些发现首次表明，在男性中，可能存在其他机制，如氧化应激导致的内皮功能障碍。
