Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), Università degli Studi di Palermo, Viale delle Scienze, ed. 17, 90128 Palermo, Italy.
Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
Molecules. 2022 Nov 1;27(21):7430. doi: 10.3390/molecules27217430.
(L.) Lindl, which belongs to the Apiaceae family, is a species that mainly grows in the eastern Mediterranean region and in western Asia. It has been largely used in traditional medicine in several countries and it has been shown to possess several interesting biological properties. With the aim to provide new insights into the phytochemistry and pharmacology of this species, the essential oils of flowers and leaves from a local accession that grows in Sicily (Italy) and has not yet been previously studied were investigated. The chemical composition of both oils, obtained by hydrodistillation from the leaves and flowers, was evaluated by GC-MS. This analysis allowed us to identify a new chemotype, characterized by a large amount of ()ocimene. Furthermore, these essential oils have been tested for their possible antimicrobial and antioxidant activity. essential oils exhibit moderate antimicrobial activity; in particular, the flower essential oil is harmful at low and wide spectrum concentrations. They also exhibit good antioxidant activity in vitro and in particular, it has been shown that the essential oils of the flowers and leaves of caused a decrease in ROS and an increase in the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione -transferase (GST) in OZ-stimulated PMNs. Therefore, these essential oils could be considered as promising candidates for pharmaceutical and nutraceutical preparations.
（L.） Lindl 属于伞形科，是一种主要生长在地中海东部地区和西亚的物种。它在几个国家的传统医学中被广泛使用，并表现出多种有趣的生物特性。为了深入了解该物种的植物化学和药理学，我们研究了在意大利西西里岛生长的当地品种的花和叶的精油，该品种尚未经过先前的研究。通过从叶子和花朵中用水蒸气蒸馏获得的两种油的化学成分通过 GC-MS 进行了评估。该分析确定了一种新的化学型，其特征在于大量存在（）-苎烯。此外，还测试了这些精油的可能的抗菌和抗氧化活性。两种精油均表现出中等的抗菌活性；特别是，在低浓度和广谱浓度下，花精油具有危害性。它们在体外也表现出良好的抗氧化活性，特别是已经表明，花和叶的精油可降低 OZ 刺激的 PMNs 中的 ROS 并增加超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽 -转移酶（GST）的活性。因此，这些精油可以被认为是制药和营养保健品的有前途的候选物。
