Fox Rina S, Zhang Manrui, Amagai Saki, Bassard Adrianna, Dworak Elizabeth M, Han Y Catherine, Kassanits Jessica, Miller Corinne H, Nowinski Cindy J, Giella Amy K, Stoeger Jordan N, Swantek Kathleen, Hook Julie N, Gershon Richard C
Northwestern University (RSF, MZ, SA, AB, EMD, YCH, JK, CHM, CJN, AKG, JNS, KS, JNH, RCG), Chicago, IL; and University of Arizona (RSF), Tucson.
Neurol Clin Pract. 2022 Aug;12(4):307-319. doi: 10.1212/CPJ.0000000000200060.
The NIH Toolbox® for the Assessment of Neurologic and Behavioral Function is a compilation of computerized measures designed to assess sensory, motor, emotional, and cognitive functioning of individuals across the life span. The NIH Toolbox was initially developed for use with the general population and was not originally validated in clinical populations. The objective of this scoping review was to assess the extent to which the NIH Toolbox has been used with clinical populations.
Guided by the Joanna Briggs Methods Manual for Scoping Reviews, records were identified through searches of PubMed MEDLINE, PsycINFO, ClinicalTrials.gov, EMBASE, and ProQuest Dissertations and Theses Global (2008-2020). Database searches yielded 5,693 unique titles of original research that used at least one NIH Toolbox assessment in a sample characterized by any clinical diagnosis. Two reviewers screened titles, abstracts, and full texts for inclusion in duplicate. Conflicts at each stage of the review process were resolved by a group discussion.
Ultimately, 281 publication records were included in this scoping review (n = 104, n = 84, n = 86, and n = 7). The NIH Toolbox Cognition Battery was by far the most used of the 4 batteries in the measurement system (n = 225, n = 49, n = 29, and n = 16). The most represented clinical category was neurologic disorders (n = 111), followed by psychological disorders (n = 39) and cancer (n = 31). Most (96.8%) of the journal articles and conference abstracts reporting the use of NIH Toolbox measures with clinical samples were published in 2015 or later. As of May 2021, these records had been cited a total of nearly 1,000 times.
The NIH Toolbox measures have been widely used among individuals with various clinical conditions across the life span. Our results lay the groundwork to support the feasibility and utility of administering the NIH Toolbox measures in research conducted with clinical populations and further suggest that these measures may be of value for implementation in fast-paced clinical settings as part of routine practice.
美国国立卫生研究院神经和行为功能评估工具包（NIH Toolbox®）是一套计算机化测量方法的汇总，旨在评估个体在整个生命周期中的感觉、运动、情感和认知功能。NIH Toolbox最初是为普通人群开发的，最初并未在临床人群中进行验证。本综述的目的是评估NIH Toolbox在临床人群中的使用程度。
以乔安娜·布里格斯循证综述方法手册为指导，通过检索PubMed MEDLINE、PsycINFO、ClinicalTrials.gov、EMBASE以及ProQuest Dissertations and Theses Global（2008 - 2020年）来识别记录。数据库检索产生了5693个独特的原始研究标题，这些研究在以任何临床诊断为特征的样本中至少使用了一项NIH Toolbox评估。两名评审员对标题、摘要和全文进行筛选，以确定是否纳入，重复进行。评审过程各阶段的冲突通过小组讨论解决。
最终，本综述纳入了281条发表记录（分别为104条、84条、86条和7条）。NIH Toolbox认知成套测验是测量系统中4个成套测验中使用最多的（分别为225条、49条、29条和16条）。最具代表性的临床类别是神经系统疾病（111条），其次是心理障碍（39条）和癌症（31条）。报告在临床样本中使用NIH Toolbox测量方法的期刊文章和会议摘要中，大多数（96.8%）发表于2015年或之后。截至2021年5月，这些记录总共被引用了近1000次。
NIH Toolbox测量方法已在不同临床状况的个体整个生命周期中广泛使用。我们的结果为支持在临床人群研究中使用NIH Toolbox测量方法的可行性和实用性奠定了基础，并进一步表明这些测量方法作为常规实践的一部分，在快节奏临床环境中实施可能具有价值。
