Department of Biology, College of Science, The United Arab Emirates University, Al Ain 15551, United Arab Emirates.
Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar.
Cells. 2022 Nov 18;11(22):3664. doi: 10.3390/cells11223664.
Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. Accumulating evidences have highlighted the importance of exosomes and non-coding RNAs (ncRNAs) in cardiac physiology and pathology. It is in general consensus that exosomes and ncRNAs play a crucial role in the maintenance of normal cellular function; and interestingly it is envisaged that their potential as prospective therapeutic candidates and biomarkers are increasing rapidly. Considering all these aspects, this review provides a comprehensive overview of the recent understanding of exosomes and ncRNAs in CVDs. We provide a great deal of discussion regarding their role in the cardiovascular system, together with providing a glimpse of ideas regarding strategies exploited to harness their potential as a therapeutic intervention and prospective biomarker against CVDs. Thus, it could be envisaged that a thorough understanding of the intricacies related to exosomes and ncRNA would seemingly allow their full exploration and may lead clinical settings to become a reality in near future.
心血管疾病（CVDs）是全球范围内主要的死亡原因之一。越来越多的证据强调了外泌体和非编码 RNA（ncRNAs）在心脏生理学和病理学中的重要性。人们普遍认为，外泌体和 ncRNAs 在维持正常细胞功能方面起着至关重要的作用；有趣的是，人们预计它们作为潜在治疗候选物和生物标志物的潜力正在迅速增加。考虑到所有这些方面，本综述全面概述了外泌体和 ncRNAs 在 CVDs 中的最新研究进展。我们详细讨论了它们在心血管系统中的作用，并提供了一些关于利用它们作为治疗干预和 CVD 潜在生物标志物的策略的想法。因此，可以预见的是，对与外泌体和 ncRNA 相关的复杂性的深入了解似乎可以允许对它们进行充分的探索，并可能使临床环境在不久的将来成为现实。
