Chen Haiyang, Zhang Lijun, Li Yanwei, Meng Xiangxi, Chi Yunpeng, Liu Meiyan
Department of Psycho-cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
School of Clinical Medicine, Henan University, Kaifeng, China.
Aging Dis. 2024 Jun 19;16(3):1265-1284. doi: 10.14336/AD.2024.0538.
The increasing studies indicated that cardiovascular diseases, such as coronary artery disease (CAD), usually induce and exacerbate psychological problems, including anxiety and depression. These psychological issues are admitted as independent risk factors of heart disease as well. The interaction between CAD and anxiety and depression deteriorates the development and prognosis of CAD, which severely threatens the quality of life of patients. Although the existing mechanisms revealed the pathological relationship between CAD and anxiety and depression, there are few studies investigating the correlation between CAD and anxiety and depression from the aspect of gut microbiota (GM) and its metabolites. Therefore, in this review, we summarized whether GM and its metabolites are the emergent bridge between CAD and anxiety and depression. The results showed that there are four kinds of jointly up-regulated bacteria (i.e., Staphylococcus, Escherichia coli, Helicobacter pylori, and Shigella) and five kinds of jointly down-regulated bacteria (i.e., Prevotella, Lactobacillus, Faecalibacterium prausnitzii, Collinsella, and Bifidobacterium) in CAD as well as anxiety and depression. In addition, in CAD and anxiety and depression, the dysbiosis of the former four kinds of bacterium frequently leads to the outburst of inflammatory response, and the dysbiosis of the latter five kinds of bacterium is usually related to the metabolic abnormality of short-chain fatty acids, bile acids, and branched-chain amino acids. Therefore, we believe that GM and its metabolites act as the emergent bridge between CAD and anxiety and depression. The findings of this review provide novel insights and approaches for the clinical treatment of patients with both CAD and anxiety and depression.
越来越多的研究表明，心血管疾病，如冠状动脉疾病（CAD），通常会诱发并加重心理问题，包括焦虑和抑郁。这些心理问题也被认为是心脏病的独立危险因素。CAD与焦虑和抑郁之间的相互作用会恶化CAD的发展和预后，严重威胁患者的生活质量。尽管现有机制揭示了CAD与焦虑和抑郁之间的病理关系，但很少有研究从肠道微生物群（GM）及其代谢产物方面探讨CAD与焦虑和抑郁之间的相关性。因此，在本综述中，我们总结了GM及其代谢产物是否是CAD与焦虑和抑郁之间的新桥梁。结果表明，在CAD以及焦虑和抑郁中，有四种共同上调的细菌（即葡萄球菌、大肠杆菌、幽门螺杆菌和志贺氏菌）和五种共同下调的细菌（即普雷沃氏菌、乳酸杆菌、普拉梭菌、柯林斯菌和双歧杆菌）。此外，在CAD以及焦虑和抑郁中，前四种细菌的失调经常导致炎症反应的爆发，而后五种细菌的失调通常与短链脂肪酸、胆汁酸和支链氨基酸的代谢异常有关。因此，我们认为GM及其代谢产物是CAD与焦虑和抑郁之间的新桥梁。本综述的研究结果为CAD合并焦虑和抑郁患者的临床治疗提供了新的见解和方法。
