School of Nursing, Jining Medical University, Jining, 272067, Shandong, China.
School of Medicine, Griffith University, Parkland Drive, Gold Coast, QLD, 4222, Australia.
Curr Hypertens Rep. 2020 Mar 21;22(5):34. doi: 10.1007/s11906-020-01042-4.
This meta-analysis and systematic review was conducted to evaluate the effect of probiotics on blood pressure, body mass index (BMI), and blood glucose changes in patients with hypertension.
We searched the PubMed, Cochrane, Embase, and ProQuest databases using a combination of MeSH and free text, from the inception of these databases to 20 January 2020, with no language restrictions. The quantitative PEDro scale method was used to assess the quality of the included studies. We used the random effects models to estimate the outcomes, with heterogeneity among the studies assessed using Cochran's Q statistic. Fourteen included studies published between 2002 and 2019 were included in the meta-analysis, reporting results of 846 hypertension participants. A significant reduction in SBP by - 2.05 mmHg (95% CI - 3.87, -0.24, P = 0.03), DBP by - 1.26 mmHg (95% CI - 2.51, - 0.004, P = 0.047), BMI by - 1.03 (95% CI - 1.28, - 0.97, P < 0.01), and blood glucose by - 0.18 mmol/L (95% CI - 0.30 - 0.05, P = 0.007) was observed following probiotics intervention. Our meta-analysis showed a modest but a significant reduction in SBP and DBP in patients with hypertension, particularly in those with diabetes mellitus, following probiotic supplementation. This effect was associated with treatment duration, dosage, and the age of subject but was not associated with single or multiple strains usage. Additionally, probiotic supplement had a beneficial effect in reducing BMI and blood glucose.
本荟萃分析和系统评价旨在评估益生菌对高血压患者血压、体重指数（BMI）和血糖变化的影响。
我们使用PubMed、Cochrane、Embase 和 ProQuest 数据库，结合 MeSH 和自由文本进行了搜索，检索时间从这些数据库建立之初到 2020 年 1 月 20 日，没有语言限制。使用定量 PEDro 量表方法评估纳入研究的质量。我们使用随机效应模型来估计结果，使用 Cochran's Q 统计量评估研究之间的异质性。纳入了 2002 年至 2019 年期间发表的 14 项研究，这些研究报告了 846 名高血压参与者的结果。益生菌干预后，收缩压降低了 -2.05mmHg（95%CI -3.87，-0.24，P=0.03），舒张压降低了 -1.26mmHg（95%CI -2.51，-0.004，P=0.047），BMI 降低了 -1.03（95%CI -1.28，-0.97，P<0.01），血糖降低了 -0.18mmol/L（95%CI -0.30 -0.05，P=0.007）。我们的荟萃分析显示，益生菌干预后，高血压患者的收缩压和舒张压有适度但显著的降低，尤其是在患有糖尿病的患者中。这种作用与治疗持续时间、剂量和受试者年龄有关，但与使用单一或多种菌株无关。此外，益生菌补充剂在降低 BMI 和血糖方面也有有益的作用。
